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10.3390/cells9081750 http://scihub22266oqcxt.onion/10.3390/cells9081750 32707842!7464076!32707842     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cells 2020 ; 9 (8): ä Nephropedia Template TP {{tp|p=32707842|t=2020. Defining the CD39/CD73 Axis in SARS-CoV-2 Infection: The CD73(-) Phenotype Identifies Polyfunctional Cytotoxic Lymphocytes |pdf=|usr=}}{{32707842}} gab.com Text Defining the CD39/CD73 Axis in SARS-CoV-2 Infection: The CD73(-) Phenotype Identifies Polyfunctional Cytotoxic Lymphocytes JO: Cells http://www.kidney.de/pget.php?&tw=1&pmid=32707842 #FOAvip The ectonucleotidases CD39 and CD73 regulate immune responses by balancing extracellular ATP and adenosine in inflammation and are likely to be involved in the pathophysiology of COVID-19. Here, we analyzed CD39 and CD73 on different lymphocyte populations in a small cohort of COVID-19 patients and in healthy individuals. We describe a significantly lower level of expression of CD73 on cytotoxic lymphocyte populations, including CD8(+) T, natural killer T (NKT), and natural killer (NK) cells, during COVID-19. Interestingly, the decrease of CD73 on CD8(+) T cells and NKT cells correlated with serum ferritin levels. Furthermore, we observed distinct functional differences between the CD73(+) and CD73(-) subsets of CD8(+) T cells and NKT cells with regard to cytokine/toxin secretion. In COVID-19 patients, the majority of the CD73(-)CD8(+) T cells were capable of secreting granzyme B, perforin, tumor necrosis factor (TNF-alpha) or interferon-gamma (IFN-gamma). To conclude, in this first study of CD39 and CD73 expression of lymphocytes in COVID-19, we show that CD8(+) T cells and NKT cells lacking CD73 possess a significantly higher cytotoxic effector functionality compared to their CD73(+) counterparts. Future studies should investigate differences of cellular CD39 and CD73 expression in patients at different disease stages and their potential as prognostic markers or targets for immunomodulatory therapies. Twit Text FOAVip Defining the CD39/CD73 Axis in SARS-CoV-2 Infection: The CD73(-) Phenotype Identifies Polyfunctional Cytotoxic Lymphocytes ????Cells http://www.kidney.de/pget.php?&tw=1&pmid=32707842 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32707842 #FOAvip English Wikipedia <ref>{{Cite pmid|32707842}}</ref> Defining the CD39/CD73 Axis in SARS-CoV-2 Infection: The CD73(-) Phenotype Identifies Polyfunctional Cytotoxic Lymphocytes #MMPMID32707842 Ahmadi P; Hartjen P; Kohsar M; Kummer S; Schmiedel S; Bockmann JH; Fathi A; Huber S; Haag F; Schulze Zur Wiesch J Cells 2020[Jul]; 9 (8): ä PMID32707842show ga The ectonucleotidases CD39 and CD73 regulate immune responses by balancing extracellular ATP and adenosine in inflammation and are likely to be involved in the pathophysiology of COVID-19. Here, we analyzed CD39 and CD73 on different lymphocyte populations in a small cohort of COVID-19 patients and in healthy individuals. We describe a significantly lower level of expression of CD73 on cytotoxic lymphocyte populations, including CD8(+) T, natural killer T (NKT), and natural killer (NK) cells, during COVID-19. Interestingly, the decrease of CD73 on CD8(+) T cells and NKT cells correlated with serum ferritin levels. Furthermore, we observed distinct functional differences between the CD73(+) and CD73(-) subsets of CD8(+) T cells and NKT cells with regard to cytokine/toxin secretion. In COVID-19 patients, the majority of the CD73(-)CD8(+) T cells were capable of secreting granzyme B, perforin, tumor necrosis factor (TNF-alpha) or interferon-gamma (IFN-gamma). To conclude, in this first study of CD39 and CD73 expression of lymphocytes in COVID-19, we show that CD8(+) T cells and NKT cells lacking CD73 possess a significantly higher cytotoxic effector functionality compared to their CD73(+) counterparts. Future studies should investigate differences of cellular CD39 and CD73 expression in patients at different disease stages and their potential as prognostic markers or targets for immunomodulatory therapies. |5'-Nucleotidase/*metabolism[MESH] |Adenosine/metabolism[MESH] |Adult[MESH] |Aged[MESH] |Apyrase/*metabolism[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |Coronavirus Infections/enzymology/*immunology[MESH] |Female[MESH] |GPI-Linked Proteins/metabolism[MESH] |Granzymes/metabolism[MESH] |Humans[MESH] |Inflammation/enzymology/immunology[MESH] |Interferon-gamma/metabolism[MESH] |Killer Cells, Natural/*immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Natural Killer T-Cells/*immunology[MESH] |Pandemics[MESH] |Perforin/metabolism[MESH] |Pneumonia, Viral/enzymology/*immunology[MESH] |SARS-CoV-2[MESH] |Signal Transduction/immunology[MESH] |T-Lymphocytes, Cytotoxic/*immunology/metabolism[MESH]Defining the CD39/CD73 Axis in SARS-CoV-2 Infection: The CD73(-) Pheno(epmc).pdf DeepDyve Pubget Overpricing