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10.1016/j.jcv.2020.104542 http://scihub22266oqcxt.onion/10.1016/j.jcv.2020.104542 32707511!7336915!32707511     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Virol 2020 ; 130 (ä): 104542 Nephropedia Template TP {{tp|p=32707511|t=2020. SARS-CoV-2-IgG response is different in COVID-19 outpatients and asymptomatic contact persons |pdf=|usr=}}{{32707511}} gab.com Text SARS-CoV-2-IgG response is different in COVID-19 outpatients and asymptomatic contact persons JO: J Clin Virol http://www.kidney.de/pget.php?&tw=1&pmid=32707511 #FOAvip Commercially available immunoassays have been developed for sensitive and specific detection of antibodies against SARS-CoV-2. While a fast and reliable IgG response has been reported for samples from hospitalized COVID-19 patients, less is known about ambulatory patients. We evaluated the SARS-CoV-2-IgG response by the Anti-SARS-CoV-2-ELISA IgG (Euroimmun) in a defined cohort of SARS-CoV-2-PCR-confirmed outpatients and asymptomatic contact persons including 137 serum samples from PCR-confirmed outpatients (n = 111) and asymptomatic but PCR-positive contact persons (n = 26) sent to our laboratory as part of routine diagnostics for determination of SARS-CoV-2-IgG. Overall positivity rate for SARS-CoV-2-IgG was 81.1 % in outpatients (irrespective of sampling before or after day 21 after onset of symptoms) but significantly lower in asymptomatic contact persons (15.4 %, p < 0.0001). In contact persons without symptoms the ct values of the PCR assays were significantly higher (5-7 threshold cycles) than in outpatients, and ct values were significantly negative correlated to the SARS-CoV-2-IgG ratio, suggesting a lower viral load as a possible explanation for lower rate of seropositivity. In summary, our study shows that serological response to SARS-CoV-2 in outpatients including asymptomatic persons is less pronounced than in hospitalized patients. Further controlled studies are urgently needed to determine serological response in outpatients and asymptomatic persons since this is the main target population for seroepidemiological investigations. Twit Text FOAVip SARS-CoV-2-IgG response is different in COVID-19 outpatients and asymptomatic contact persons ????J Clin Virol http://www.kidney.de/pget.php?&tw=1&pmid=32707511 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32707511 #FOAvip English Wikipedia <ref>{{Cite pmid|32707511}}</ref> SARS-CoV-2-IgG response is different in COVID-19 outpatients and asymptomatic contact persons #MMPMID32707511 Wellinghausen N; Plonne D; Voss M; Ivanova R; Frodl R; Deininger S J Clin Virol 2020[Sep]; 130 (ä): 104542 PMID32707511show ga Commercially available immunoassays have been developed for sensitive and specific detection of antibodies against SARS-CoV-2. While a fast and reliable IgG response has been reported for samples from hospitalized COVID-19 patients, less is known about ambulatory patients. We evaluated the SARS-CoV-2-IgG response by the Anti-SARS-CoV-2-ELISA IgG (Euroimmun) in a defined cohort of SARS-CoV-2-PCR-confirmed outpatients and asymptomatic contact persons including 137 serum samples from PCR-confirmed outpatients (n = 111) and asymptomatic but PCR-positive contact persons (n = 26) sent to our laboratory as part of routine diagnostics for determination of SARS-CoV-2-IgG. Overall positivity rate for SARS-CoV-2-IgG was 81.1 % in outpatients (irrespective of sampling before or after day 21 after onset of symptoms) but significantly lower in asymptomatic contact persons (15.4 %, p < 0.0001). In contact persons without symptoms the ct values of the PCR assays were significantly higher (5-7 threshold cycles) than in outpatients, and ct values were significantly negative correlated to the SARS-CoV-2-IgG ratio, suggesting a lower viral load as a possible explanation for lower rate of seropositivity. In summary, our study shows that serological response to SARS-CoV-2 in outpatients including asymptomatic persons is less pronounced than in hospitalized patients. Further controlled studies are urgently needed to determine serological response in outpatients and asymptomatic persons since this is the main target population for seroepidemiological investigations. |Antibodies, Viral/*blood[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |Carrier State/*immunology/virology[MESH] |Cohort Studies[MESH] |Coronavirus Infections/*immunology[MESH] |Germany[MESH] |Humans[MESH] |Immunoassay[MESH] |Immunoglobulin G/*blood[MESH] |Outpatients[MESH] |Pandemics[MESH] |Pneumonia, Viral/*immunology[MESH] |SARS-CoV-2[MESH] |Sensitivity and Specificity[MESH]SARS-CoV-2-IgG response is different in COVID-19 outpatients and asymp(epmc).pdf DeepDyve Pubget Overpricing