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10.1016/j.chom.2020.07.005

http://scihub22266oqcxt.onion/10.1016/j.chom.2020.07.005
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32707096!7368656!32707096
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suck abstract from ncbi


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pmid32707096      Cell+Host+Microbe 2020 ; 28 (3): 455-464.e2
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  • Retrospective Multicenter Cohort Study Shows Early Interferon Therapy Is Associated with Favorable Clinical Responses in COVID-19 Patients #MMPMID32707096
  • Wang N; Zhan Y; Zhu L; Hou Z; Liu F; Song P; Qiu F; Wang X; Zou X; Wan D; Qian X; Wang S; Guo Y; Yu H; Cui M; Tong G; Xu Y; Zheng Z; Lu Y; Hong P
  • Cell Host Microbe 2020[Sep]; 28 (3): 455-464.e2 PMID32707096show ga
  • Interferons (IFNs) are widely used in treating coronavirus disease 2019 (COVID-19) patients. However, a recent report of ACE2, the host factor mediating SARS-Cov-2 infection, identifying it as interferon-stimulated raised considerable safety concern. To examine the association between the use and timing of IFN-alpha2b and clinical outcomes, we analyzed in a retrospective multicenter cohort study of 446 COVID-19 patients in Hubei, China. Regression models estimated that early administration (
  • |*Betacoronavirus[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Antiviral Agents/*administration & dosage/therapeutic use[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Child[MESH]
  • |China/epidemiology[MESH]
  • |Cohort Studies[MESH]
  • |Coronavirus Infections/*drug therapy/epidemiology/mortality[MESH]
  • |Drug Therapy, Combination[MESH]
  • |Female[MESH]
  • |Hospital Mortality[MESH]
  • |Host Microbial Interactions/drug effects[MESH]
  • |Humans[MESH]
  • |Indoles/administration & dosage[MESH]
  • |Interferon alpha-2[MESH]
  • |Interferon-alpha/administration & dosage/*therapeutic use[MESH]
  • |Length of Stay[MESH]
  • |Lopinavir/administration & dosage[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy/epidemiology/mortality[MESH]
  • |Retrospective Studies[MESH]
  • |Ritonavir/administration & dosage[MESH]
  • |SARS-CoV-2[MESH]
  • |Treatment Outcome[MESH]


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