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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cell+Host+Microbe 2020 ; 28 (3): 455-464.e2 Nephropedia Template TP
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Retrospective Multicenter Cohort Study Shows Early Interferon Therapy Is Associated with Favorable Clinical Responses in COVID-19 Patients #MMPMID32707096
Wang N; Zhan Y; Zhu L; Hou Z; Liu F; Song P; Qiu F; Wang X; Zou X; Wan D; Qian X; Wang S; Guo Y; Yu H; Cui M; Tong G; Xu Y; Zheng Z; Lu Y; Hong P
Cell Host Microbe 2020[Sep]; 28 (3): 455-464.e2 PMID32707096show ga
Interferons (IFNs) are widely used in treating coronavirus disease 2019 (COVID-19) patients. However, a recent report of ACE2, the host factor mediating SARS-Cov-2 infection, identifying it as interferon-stimulated raised considerable safety concern. To examine the association between the use and timing of IFN-alpha2b and clinical outcomes, we analyzed in a retrospective multicenter cohort study of 446 COVID-19 patients in Hubei, China. Regression models estimated that early administration (=5 days after admission) of IFN-alpha2b was associated with reduced in-hospital mortality in comparison with no admission of IFN-alpha2b, whereas late administration of IFN-alpha2b was associated with increased mortality. Among survivors, early IFN-alpha2b was not associated with hospital discharge or computed tomography (CT) scan improvement, whereas late IFN-alpha2b was associated with delayed recovery. Additionally, early IFN-alpha2b and umifenovir alone or together were associated with reduced mortality and accelerated recovery in comparison with treatment with lopinavir/ritonavir (LPV/r) alone. We concluded that administration of IFN-alpha2b during the early stage of COVID-19 could induce favorable clinical responses.