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10.1002/jmv.26352

http://scihub22266oqcxt.onion/10.1002/jmv.26352
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32706409!7404443!32706409
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suck abstract from ncbi


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pmid32706409      J+Med+Virol 2021 ; 93 (2): 1145-1149
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  • SARS-CoV-2 infection in persons living with HIV: A single center prospective cohort #MMPMID32706409
  • Maggiolo F; Zoboli F; Arosio M; Valenti D; Guarneri D; Sangiorgio L; Ripamonti D; Callegaro A
  • J Med Virol 2021[Feb]; 93 (2): 1145-1149 PMID32706409show ga
  • Information about severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in HIV-infected individuals is scarce. In this prospective study, we included HIV (human immunodefeciency virus)-infected individuals (people living with HIV [PLWHIV]) with confirmed SARS-CoV-2 infection and compared them with PLWHIV negative for SARS-CoV-2. We compared 55 cases of SARS-CoV-2 infection with 69 asymptomatic PLWHIV negative for SARS-CoV-2 reverse transcription-polymerase chain reaction and/or serology. There was no significant difference between SARS-CoV-2 positive or negative patients for age distribution, gender, time with HIV infection, nadir CD4-cell counts, type and number of co-morbidities, current CD4 and CD8 counts and type of anti-HIV therapy. Positive patients presented with a median of three symptoms (interquartile range, 1-3). Most common symptoms were fever (76%), dyspnea (35%), anosmia (29%) non-productive cough (27%), fatigue 22%), and ageusia (20%). Ten patients (18%) were completely asymptomatic. Four (7.2%) subjects died of coronavirus disease 2019. Factors significantly (P < .05) associated with death included age and number of co-morbidities, while time from HIV infection and lower current CD4 counts were significant only in univariate analysis. HIV-infected individuals are not protected from SARS-CoV-2 infection or have a lower risk of severe disease. Indeed, those with low CD4 cell counts might have worse outcomes. Infection is asymptomatic in a large proportion of subjects and this is relevant for epidemiological studies.
  • |Age Distribution[MESH]
  • |CD4 Lymphocyte Count/statistics & numerical data[MESH]
  • |CD8-Positive T-Lymphocytes/immunology[MESH]
  • |COVID-19/*epidemiology/mortality/*virology[MESH]
  • |Comorbidity[MESH]
  • |Female[MESH]
  • |HIV Infections/*epidemiology/virology[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Prospective Studies[MESH]


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