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10.1002/jmv.26336

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32706396!7404826!32706396
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suck abstract from ncbi


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pmid32706396      J+Med+Virol 2021 ; 93 (2): 962-972
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  • Coagulation dysfunction is associated with severity of COVID-19: A meta-analysis #MMPMID32706396
  • Zhu J; Pang J; Ji P; Zhong Z; Li H; Li B; Zhang J; Lu J
  • J Med Virol 2021[Feb]; 93 (2): 962-972 PMID32706396show ga
  • To systematically analyze the blood coagulation features of coronavirus disease 2019 (COVID-19) patients to provide a reference for clinical practice. An electronic search in PubMed, EMbase, Web of Science, Scopus, CNKI, WanFang Data, and VIP databases to identify studies describing the blood coagulation features of COVID-19 patients from 1 January 2020 to 21 April 2020. Three reviewers independently screened literature, extracted data, and assessed the risk of bias of included studies, then, the meta-analysis was performed by using Stata 12.0 software. Thirty-four studies involving 6492 COVID-19 patients were included. Meta-analysis showed that patients with severe disease showed significantly lower platelet count (weighted mean differences [WMD]: -16.29 x 10(9) /L; 95% confidence interval [CI]: -25.34 to -7.23) and shorter activated partial thromboplastin time (WMD: -0.81 seconds; 95% CI: -1.94 to 0.33) but higher D-dimer levels (WMD: 0.44 mug/mL; 95% CI: 0.29-0.58), higher fibrinogen levels (WMD: 0.51 g/L; 95% CI: 0.33-0.69) and longer prothrombin time (PT; WMD: 0.65 seconds; 95% CI: 0.44-0.86). Patients who died showed significantly higher D-dimer levels (WMD: 6.58 mug/mL; 95% CI: 3.59-9.57), longer PT (WMD: 1.27 seconds; 95% CI: 0.49-2.06) and lower platelet count (WMD: -39.73 x 10(9) /L; 95% CI: -61.99 to -17.45) than patients who survived. Coagulation dysfunction is common in severe COVID-19 patients and it is associated with severity of COVID-19.
  • |Blood Coagulation Disorders/*virology[MESH]
  • |COVID-19/*complications/*mortality[MESH]
  • |Fibrin Fibrinogen Degradation Products/analysis[MESH]
  • |Fibrinogen/analysis[MESH]
  • |Humans[MESH]
  • |Leukocyte Count[MESH]
  • |Platelet Count[MESH]
  • |Prothrombin Time[MESH]


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