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Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Eur+Rev+Med+Pharmacol+Sci 2020 ; 24 (13): 7475-7484 Nephropedia Template TP
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A systematic review on the efficacy and safety of IL-6 modulatory drugs in the treatment of COVID-19 patients #MMPMID32706087
Solis-Garcia Del Pozo J; Galindo MF; Nava E; Jordan J
Eur Rev Med Pharmacol Sci 2020[Jul]; 24 (13): 7475-7484 PMID32706087show ga
The pandemic caused by the new SARS-CoV2 coronavirus has led to an effort to find treatments that are effective against this disease that the World Health Organization calls COVID-19. In severe cases of COVID-19, there is an increase in cytokines, among which IL-6 seems to play an important role. A search has been performed for studies using IL-6 blocking drugs (tocilizumab, siltuximab, and sarilumab) in PubMed, Web of Science, and Scopus. Also, a search of ongoing trials registered at clinicaltrials.gov was performed. We found very little published clinical experience with these drugs, consisting mainly of case reports or case series with few patients. The results of clinical trials are necessary to clarify the role of these drugs in patients with COVID-19.