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10.1007/s40520-020-01653-6

http://scihub22266oqcxt.onion/10.1007/s40520-020-01653-6
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32705587!7377312!32705587
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suck abstract from ncbi


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pmid32705587      Aging+Clin+Exp+Res 2020 ; 32 (9): 1897-1905
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  • COVID-19 and associations with frailty and multimorbidity: a prospective analysis of UK Biobank participants #MMPMID32705587
  • Woolford SJ; D'Angelo S; Curtis EM; Parsons CM; Ward KA; Dennison EM; Patel HP; Cooper C; Harvey NC
  • Aging Clin Exp Res 2020[Sep]; 32 (9): 1897-1905 PMID32705587show ga
  • BACKGROUND: Frailty and multimorbidity have been suggested as risk factors for severe COVID-19 disease. AIMS: We investigated, in the UK Biobank, whether frailty and multimorbidity were associated with risk of hospitalisation with COVID-19. METHODS: 502,640 participants aged 40-69 years at baseline (54-79 years at COVID-19 testing) were recruited across UK during 2006-10. A modified assessment of frailty using Fried's classification was generated from baseline data. COVID-19 test results (England) were available for 16/03/2020-01/06/2020, mostly taken in hospital settings. Logistic regression was used to discern associations between frailty, multimorbidity and COVID-19 diagnoses, after adjusting for sex, age, BMI, ethnicity, education, smoking and number of comorbidity groupings, comparing COVID-19 positive, COVID-19 negative and non-tested groups. RESULTS: 4510 participants were tested for COVID-19 (positive = 1326, negative = 3184). 497,996 participants were not tested. Compared to the non-tested group, after adjustment, COVID-19 positive participants were more likely to be frail (OR = 1.4 [95%CI = 1.1, 1.8]), report slow walking speed (OR = 1.3 [1.1, 1.6]), report two or more falls in the past year (OR = 1.3 [1.0, 1.5]) and be multimorbid (>/= 4 comorbidity groupings vs 0-1: OR = 1.9 [1.5, 2.3]). However, similar strength of associations were apparent when comparing COVID-19 negative and non-tested groups. However, frailty and multimorbidity were not associated with COVID-19 diagnoses, when comparing COVID-19 positive and COVID-19 negative participants. DISCUSSION AND CONCLUSIONS: Frailty and multimorbidity do not appear to aid risk stratification, in terms of positive versus negative results of COVID-19 testing. Investigation of the prognostic value of these markers for adverse clinical sequelae following COVID-19 disease is urgently needed.
  • |*Clinical Laboratory Techniques/methods/statistics & numerical data[MESH]
  • |*Coronavirus Infections/diagnosis/epidemiology[MESH]
  • |*Frailty/diagnosis/epidemiology[MESH]
  • |*Multimorbidity[MESH]
  • |*Musculoskeletal Diseases/diagnosis/epidemiology[MESH]
  • |*Pandemics[MESH]
  • |*Pneumonia, Viral/diagnosis/epidemiology[MESH]
  • |Aged[MESH]
  • |Betacoronavirus/isolation & purification[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |Female[MESH]
  • |Geriatric Assessment/methods/statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Prognosis[MESH]
  • |Prospective Studies[MESH]
  • |Risk Assessment/methods[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]


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