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10.3892/ijmm.2020.4646 http://scihub22266oqcxt.onion/10.3892/ijmm.2020.4646 32705281!7388840!32705281     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 296.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Med 2020 ; 46 (3): 949-956 Nephropedia Template TP {{tp|p=32705281|t=2020. Co?expression of peripheral olfactory receptors with SARS?CoV?2 infection mediators: Potential implications beyond loss of smell as a COVID?19 symptom |pdf=|usr=}}{{32705281}} gab.com Text Co expression of peripheral olfactory receptors with SARS CoV 2 infection mediators: Potential implications beyond loss of smell as a COVID 19 symptom JO: Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=32705281 #FOAvip Severe acute respiratory syndrome (SARS) coronavirus?2 (SARS?CoV?2) enters into human host cells via mechanisms facilitated mostly by angiotensin?converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2). New loss of smell (anosmia/hyposmia) is now recognized as a COVID?19 related symptom, which may be caused by SARS?CoV?2 infection and damage of the olfactory receptor (OR) cells in the nasal neuro?epithelium and/or central involvement of the olfactory bulb. ORs are also expressed peripherally (e.g., in tissues of the gastrointestinal and respiratory systems) and it is possible that their local functions could also be impaired by SARS?CoV?2 infection of these tissues. Using Gene Expression Profiling Interactive Analysis, The Cancer Genome Atlas, Genotype?Tissue Expression, cBioPortal and Shiny Methylation Analysis Resource Tool, we highlight the expression of peripheral ORs in both healthy and malignant tissues, and describe their co?expression with key mediators of SARS?CoV?2 infection, such as ACE2 and TMPRSS2, as well as cathepsin L (CTSL; another cellular protease mediating SARS?CoV?2 infection of host cells). A wide expression profile of peripheral ORs was noted, particularly in tissues such as the prostate, testis, thyroid, brain, liver, kidney and bladder, as well as tissues with known involvement in cardio?metabolic disease (e.g., the adipose tissue, pancreas and heart). Among these, OR51E2, in particular, was significantly upregulated in prostate adenocarcinoma (PRAD) and co?expressed primarily with TMPRSS2. Functional networks of this OR were further analysed using the GeneMANIA interactive tool, showing that OR51E2 interacts with a plethora of genes related to the prostate. Further in vitro and clinical studies are clearly required to elucidate the role of ORs, both at the olfactory level and the periphery, in the context of COVID?19. Twit Text FOAVip Co expression of peripheral olfactory receptors with SARS CoV 2 infection mediators: Potential implications beyond loss of smell as a COVID 19 symptom ????Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=32705281 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32705281 #FOAvip English Wikipedia <ref>{{Cite pmid|32705281}}</ref> Co?expression of peripheral olfactory receptors with SARS?CoV?2 infection mediators: Potential implications beyond loss of smell as a COVID?19 symptom #MMPMID32705281 Kerslake R; Hall M; Randeva HS; Spandidos DA; Chatha K; Kyrou I; Karteris E Int J Mol Med 2020[Sep]; 46 (3): 949-956 PMID32705281show ga Severe acute respiratory syndrome (SARS) coronavirus?2 (SARS?CoV?2) enters into human host cells via mechanisms facilitated mostly by angiotensin?converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2). New loss of smell (anosmia/hyposmia) is now recognized as a COVID?19 related symptom, which may be caused by SARS?CoV?2 infection and damage of the olfactory receptor (OR) cells in the nasal neuro?epithelium and/or central involvement of the olfactory bulb. ORs are also expressed peripherally (e.g., in tissues of the gastrointestinal and respiratory systems) and it is possible that their local functions could also be impaired by SARS?CoV?2 infection of these tissues. Using Gene Expression Profiling Interactive Analysis, The Cancer Genome Atlas, Genotype?Tissue Expression, cBioPortal and Shiny Methylation Analysis Resource Tool, we highlight the expression of peripheral ORs in both healthy and malignant tissues, and describe their co?expression with key mediators of SARS?CoV?2 infection, such as ACE2 and TMPRSS2, as well as cathepsin L (CTSL; another cellular protease mediating SARS?CoV?2 infection of host cells). A wide expression profile of peripheral ORs was noted, particularly in tissues such as the prostate, testis, thyroid, brain, liver, kidney and bladder, as well as tissues with known involvement in cardio?metabolic disease (e.g., the adipose tissue, pancreas and heart). Among these, OR51E2, in particular, was significantly upregulated in prostate adenocarcinoma (PRAD) and co?expressed primarily with TMPRSS2. Functional networks of this OR were further analysed using the GeneMANIA interactive tool, showing that OR51E2 interacts with a plethora of genes related to the prostate. Further in vitro and clinical studies are clearly required to elucidate the role of ORs, both at the olfactory level and the periphery, in the context of COVID?19. |Angiotensin-Converting Enzyme 2/*genetics[MESH] |Anosmia/*etiology/genetics[MESH] |COVID-19/*complications/genetics[MESH] |Gene Expression Profiling[MESH] |Gene Regulatory Networks[MESH] |Genomics[MESH] |Humans[MESH] |Male[MESH] |Neoplasm Proteins/*genetics[MESH] |Neoplasms/genetics[MESH] |Prostatic Neoplasms/genetics[MESH] |Receptors, Odorant/*genetics[MESH] |SARS-CoV-2/isolation & purification[MESH] |Serine Endopeptidases/*genetics[MESH]Co?expression of peripheral olfactory receptors with SARS?CoV?2 infect(epmc).pdf DeepDyve Pubget Overpricing