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10.12688/f1000research.23729.1 http://scihub22266oqcxt.onion/10.12688/f1000research.23729.1 32704352!7359749!32704352     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32704352&cmd=llinks): Failed to open stream: HTTP request failed! 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Recruiting the innate immune system with GM-CSF to fight viral diseases, including West Nile Virus encephalitis and COVID-19 |pdf=|usr=}}{{32704352}} gab.com Text Recruiting the innate immune system with GM-CSF to fight viral diseases, including West Nile Virus encephalitis and COVID-19 JO: F1000Res http://www.kidney.de/pget.php?&tw=1&pmid=32704352 #FOAvip As the coronavirus disease 2019 (COVID-19) pandemic grows throughout the world, it is imperative that all approaches to ameliorating its effects be investigated, including repurposing drugs that show promise in other diseases. We have been investigating an approach to multiple disorders that involves recruiting the innate immune system to aid the body's healing and regenerative mechanism(s). In the case of West Nile Virus encephalitis and potentially COVID-19, the proposed intervention to stimulate the innate immune system may give the adaptive immune response the necessary time to develop, finish clearing the virus, and provide future immunity. Furthermore, we have found that GM-CSF-induced recruitment of the innate immune system is also able to reverse brain pathology, neuroinflammation and cognitive deficits in mouse models of Alzheimer's disease and Down syndrome, as well as improving cognition in normal aging and in human patients with cognitive deficits due to chemotherapy, both of which exhibit neuroinflammation. Others have shown that GM-CSF is an effective treatment for both bacterial and viral pneumonias, and their associated inflammation, in animals and that it has successfully treated pneumonia-associated Acute Respiratory Distress Syndrome in humans. These and other data strongly suggest that GM-CSF may be an effective treatment for many viral infections, including COVID-19. Twit Text FOAVip Recruiting the innate immune system with GM-CSF to fight viral diseases, including West Nile Virus encephalitis and COVID-19 ????F1000Res http://www.kidney.de/pget.php?&tw=1&pmid=32704352 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32704352 #FOAvip English Wikipedia <ref>{{Cite pmid|32704352}}</ref> Recruiting the innate immune system with GM-CSF to fight viral diseases, including West Nile Virus encephalitis and COVID-19 #MMPMID32704352 Potter H; Boyd TD; Clarke P; Pelak VS; Tyler KL F1000Res 2020[]; 9 (ä): 345 PMID32704352show ga As the coronavirus disease 2019 (COVID-19) pandemic grows throughout the world, it is imperative that all approaches to ameliorating its effects be investigated, including repurposing drugs that show promise in other diseases. We have been investigating an approach to multiple disorders that involves recruiting the innate immune system to aid the body's healing and regenerative mechanism(s). In the case of West Nile Virus encephalitis and potentially COVID-19, the proposed intervention to stimulate the innate immune system may give the adaptive immune response the necessary time to develop, finish clearing the virus, and provide future immunity. Furthermore, we have found that GM-CSF-induced recruitment of the innate immune system is also able to reverse brain pathology, neuroinflammation and cognitive deficits in mouse models of Alzheimer's disease and Down syndrome, as well as improving cognition in normal aging and in human patients with cognitive deficits due to chemotherapy, both of which exhibit neuroinflammation. Others have shown that GM-CSF is an effective treatment for both bacterial and viral pneumonias, and their associated inflammation, in animals and that it has successfully treated pneumonia-associated Acute Respiratory Distress Syndrome in humans. These and other data strongly suggest that GM-CSF may be an effective treatment for many viral infections, including COVID-19. |*Immune System[MESH] |Animals[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |Coronavirus Infections/*immunology/therapy[MESH] |Encephalitis/therapy/virology[MESH] |Granulocyte-Macrophage Colony-Stimulating Factor/*immunology/*therapeutic use[MESH] |Humans[MESH] |Mice[MESH] |Pandemics[MESH] |Pneumonia, Viral/*immunology/therapy[MESH] |SARS-CoV-2[MESH]Recruiting the innate immune system with GM-CSF to fight viral disease(epmc).pdf DeepDyve Pubget Overpricing