Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/s41564-020-0769-y http://scihub22266oqcxt.onion/10.1038/s41564-020-0769-y 32704094!7916999!32704094     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Microbiol 2020 ; 5 (11): 1330-1339 Nephropedia Template TP {{tp|p=32704094|t=2020. LY6E impairs coronavirus fusion and confers immune control of viral disease |pdf=|usr=}}{{32704094}} gab.com Text LY6E impairs coronavirus fusion and confers immune control of viral disease JO: Nat Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=32704094 #FOAvip Zoonotic coronaviruses (CoVs) are substantial threats to global health, as exemplified by the emergence of two severe acute respiratory syndrome CoVs (SARS-CoV and SARS-CoV-2) and Middle East respiratory syndrome CoV (MERS-CoV) within two decades(1-3). Host immune responses to CoVs are complex and regulated in part through antiviral interferons. However, interferon-stimulated gene products that inhibit CoVs are not well characterized(4). Here, we show that lymphocyte antigen 6 complex, locus E (LY6E) potently restricts infection by multiple CoVs, including SARS-CoV, SARS-CoV-2 and MERS-CoV. Mechanistic studies revealed that LY6E inhibits CoV entry into cells by interfering with spike protein-mediated membrane fusion. Importantly, mice lacking Ly6e in immune cells were highly susceptible to a murine CoV-mouse hepatitis virus. Exacerbated viral pathogenesis in Ly6e knockout mice was accompanied by loss of hepatic immune cells, higher splenic viral burden and reduction in global antiviral gene pathways. Accordingly, we found that constitutive Ly6e directly protects primary B cells from murine CoV infection. Our results show that LY6E is a critical antiviral immune effector that controls CoV infection and pathogenesis. These findings advance our understanding of immune-mediated control of CoV in vitro and in vivo-knowledge that could help inform strategies to combat infection by emerging CoVs. Twit Text FOAVip LY6E impairs coronavirus fusion and confers immune control of viral disease ????Nat Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=32704094 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32704094 #FOAvip English Wikipedia <ref>{{Cite pmid|32704094}}</ref> LY6E impairs coronavirus fusion and confers immune control of viral disease #MMPMID32704094 Pfaender S; Mar KB; Michailidis E; Kratzel A; Boys IN; V'kovski P; Fan W; Kelly JN; Hirt D; Ebert N; Stalder H; Kleine-Weber H; Hoffmann M; Hoffmann HH; Saeed M; Dijkman R; Steinmann E; Wight-Carter M; McDougal MB; Hanners NW; Pohlmann S; Gallagher T; Todt D; Zimmer G; Rice CM; Schoggins JW; Thiel V Nat Microbiol 2020[Nov]; 5 (11): 1330-1339 PMID32704094show ga Zoonotic coronaviruses (CoVs) are substantial threats to global health, as exemplified by the emergence of two severe acute respiratory syndrome CoVs (SARS-CoV and SARS-CoV-2) and Middle East respiratory syndrome CoV (MERS-CoV) within two decades(1-3). Host immune responses to CoVs are complex and regulated in part through antiviral interferons. However, interferon-stimulated gene products that inhibit CoVs are not well characterized(4). Here, we show that lymphocyte antigen 6 complex, locus E (LY6E) potently restricts infection by multiple CoVs, including SARS-CoV, SARS-CoV-2 and MERS-CoV. Mechanistic studies revealed that LY6E inhibits CoV entry into cells by interfering with spike protein-mediated membrane fusion. Importantly, mice lacking Ly6e in immune cells were highly susceptible to a murine CoV-mouse hepatitis virus. Exacerbated viral pathogenesis in Ly6e knockout mice was accompanied by loss of hepatic immune cells, higher splenic viral burden and reduction in global antiviral gene pathways. Accordingly, we found that constitutive Ly6e directly protects primary B cells from murine CoV infection. Our results show that LY6E is a critical antiviral immune effector that controls CoV infection and pathogenesis. These findings advance our understanding of immune-mediated control of CoV in vitro and in vivo-knowledge that could help inform strategies to combat infection by emerging CoVs. |Angiotensin-Converting Enzyme 2[MESH] |Animals[MESH] |Antigens, Surface/genetics/immunology/*metabolism[MESH] |Betacoronavirus/immunology/physiology[MESH] |COVID-19[MESH] |Coronavirus Infections/*immunology/*virology[MESH] |Coronavirus/immunology/*physiology[MESH] |Female[MESH] |GPI-Linked Proteins/genetics/immunology/*metabolism[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Mice, Knockout[MESH] |Middle East Respiratory Syndrome Coronavirus/immunology/physiology[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/metabolism[MESH] |Pneumonia, Viral/immunology/virology[MESH] |SARS-CoV-2[MESH] |Severe acute respiratory syndrome-related coronavirus/immunology/physiology[MESH]LY6E impairs coronavirus fusion and confers immune control of viral di(epmc).pdf DeepDyve Pubget Overpricing