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10.1038/s41598-020-69342-y http://scihub22266oqcxt.onion/10.1038/s41598-020-69342-y 32704018!7378049!32704018     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2020 ; 10 (1): 12331 Nephropedia Template TP {{tp|p=32704018|t=2020. Human SARS-CoV-2 has evolved to reduce CG dinucleotide in its open reading frames |pdf=|usr=}}{{32704018}} gab.com Text Human SARS-CoV-2 has evolved to reduce CG dinucleotide in its open reading frames JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=32704018 #FOAvip The outbreak of COVID-19 has brought great threat to human health. Its causative agent is a severe acute respiratory syndrome-related coronavirus which has been officially named SARS-CoV-2. Here we report the discovery of extremely low CG abundance in its open reading frames. We found that CG reduction in SARS-CoV-2 is achieved mainly through mutating C/G into A/T, and CG is the best target for mutation. Meanwhile, 5'-untranslated region of SARS-CoV-2 has high CG content and is capable of forming an internal ribosome entry site (IRES) to recruit host ribosome for translating its RNA. These features allow SARS-CoV-2 to reproduce efficiently in host cells, because less energy is consumed in disrupting the stem-loops formed by its genomic RNA. Notably, genomes of cellular organisms also have very low CG abundance, suggesting that mutating C/G into A/T occurs universally in all life forms. Moreover, CG is the dinucleotide related to CpG island, mutational hotspot and single nucleotide polymorphism in cellular organisms. The relationship between these features is worthy of further investigations. Twit Text FOAVip Human SARS-CoV-2 has evolved to reduce CG dinucleotide in its open reading frames ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=32704018 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32704018 #FOAvip English Wikipedia <ref>{{Cite pmid|32704018}}</ref> Human SARS-CoV-2 has evolved to reduce CG dinucleotide in its open reading frames #MMPMID32704018 Wang Y; Mao JM; Wang GD; Luo ZP; Yang L; Yao Q; Chen KP Sci Rep 2020[Jul]; 10 (1): 12331 PMID32704018show ga The outbreak of COVID-19 has brought great threat to human health. Its causative agent is a severe acute respiratory syndrome-related coronavirus which has been officially named SARS-CoV-2. Here we report the discovery of extremely low CG abundance in its open reading frames. We found that CG reduction in SARS-CoV-2 is achieved mainly through mutating C/G into A/T, and CG is the best target for mutation. Meanwhile, 5'-untranslated region of SARS-CoV-2 has high CG content and is capable of forming an internal ribosome entry site (IRES) to recruit host ribosome for translating its RNA. These features allow SARS-CoV-2 to reproduce efficiently in host cells, because less energy is consumed in disrupting the stem-loops formed by its genomic RNA. Notably, genomes of cellular organisms also have very low CG abundance, suggesting that mutating C/G into A/T occurs universally in all life forms. Moreover, CG is the dinucleotide related to CpG island, mutational hotspot and single nucleotide polymorphism in cellular organisms. The relationship between these features is worthy of further investigations. |5' Untranslated Regions[MESH] |Betacoronavirus/*genetics/isolation & purification[MESH] |COVID-19[MESH] |Coronavirus Infections/pathology/*virology[MESH] |CpG Islands[MESH] |Dinucleoside Phosphates/*metabolism[MESH] |Humans[MESH] |Nucleic Acid Conformation[MESH] |Odds Ratio[MESH] |Open Reading Frames/*genetics[MESH] |Pandemics[MESH] |Pneumonia, Viral/pathology/*virology[MESH] |Polymorphism, Single Nucleotide[MESH] |SARS-CoV-2[MESH]Human SARS-CoV-2 has evolved to reduce CG dinucleotide in its open rea(epmc).pdf DeepDyve Pubget Overpricing