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suck abstract from ncbi


10.1128/mBio.01723-20

http://scihub22266oqcxt.onion/10.1128/mBio.01723-20
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32703911!7378262!32703911
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suck abstract from ncbi

pmid32703911      mBio 2020 ; 11 (4): ?
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  • Can Dietary Fatty Acids Affect the COVID-19 Infection Outcome in Vulnerable Populations? #MMPMID32703911
  • Onishi JC; Haggblom MM; Shapses SA
  • mBio 2020[Jul]; 11 (4): ? PMID32703911show ga
  • There is high mortality in coronavirus disease 2019 (COVID-19)-infected individuals with chronic inflammatory diseases, like obesity, diabetes, and hypertension. A cytokine storm in some patients after infection contributes to this mortality. In addition to lungs, the intestine is targeted during COVID-19 infection. The intestinal membrane serves as a barrier to prevent leakage of microorganisms and their products into the bloodstream; however, dietary fats can affect the gut microbiome and may increase intestinal permeability. In obese or diabetic individuals, there is an increase in the abundance of either Gram-negative bacteria in the gut or their product, endotoxin, in systemic circulation. We speculate that when the COVID-19 infection localizes in the intestine and when the permeability properties of the intestinal membrane are compromised, an inflammatory response is generated when proinflammatory endotoxin, produced by resident Gram-negative bacteria, leaks into the systemic circulation. This review discusses conditions contributing to inflammation that are triggered by microbially derived factors from the gut.
  • |*Betacoronavirus[MESH]
  • |Animals[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*complications[MESH]
  • |Cytokine Release Syndrome/etiology[MESH]
  • |Dietary Fats/*administration & dosage[MESH]
  • |Fatty Acids/*administration & dosage[MESH]
  • |Gastrointestinal Microbiome/physiology[MESH]
  • |Humans[MESH]
  • |Inflammation/etiology[MESH]
  • |Mice[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*complications[MESH]


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