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10.1016/j.bbrc.2020.05.179 http://scihub22266oqcxt.onion/10.1016/j.bbrc.2020.05.179 32703421!7831678!32703421     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochem+Biophys+Res+Commun 2020 ; 529 (2): 263-269 Nephropedia Template TP {{tp|p=32703421|t=2020. Genetic variants that influence SARS-CoV-2 receptor TMPRSS2 expression among population cohorts from multiple continents |pdf=|usr=}}{{32703421}} gab.com Text Genetic variants that influence SARS-CoV-2 receptor TMPRSS2 expression among population cohorts from multiple continents JO: Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=32703421 #FOAvip The World Health Organization recently announced that pandemic status has been achieved for coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Exponential increases in patient numbers have been reported around the world, along with proportional increases in the number of COVID-19-related deaths. The SARS-CoV-2 infection rate in a population is expected to be influenced by social practices, availability of vaccines or prophylactics, and the prevalence of susceptibility genes in the population. Previous work revealed that cellular uptake of SARS-CoV-2 requires Angiotensin Converting Enzyme 2 (ACE-2) and a cellular protease. The spike (S) protein on SARS-CoV-2 binds ACE-2, which functions as an entry receptor. Following receptor binding, transmembrane protease serine 2 (encoded by TMPRSS2) primes the S protein to allow cellular uptake. Therefore, individual expression of TMPRSS2 may be a crucial determinant of SARS-CoV-2 infection susceptibility. Here, we utilized multiple large genome databases, including the GTEx portal, SNP nexus, and Ensembl genome project, to identify gene expression profiles for TMPRSS2 and its important expression quantitative trait loci. Our results show that four variants (rs464397, rs469390, rs2070788 and rs383510) affect expression of TMPRSS2 in lung tissue. The allele frequency of each variant was then assessed in regional populations, including African, American, European, and three Asian cohorts (China, Japan and Taiwan). Interestingly, our data shows that TMPRSS2-upregulating variants are at higher frequencies in European and American populations than in the Asian populations, which implies that these populations might be relatively susceptible to SARS-CoV-2 infection. Twit Text FOAVip Genetic variants that influence SARS-CoV-2 receptor TMPRSS2 expression among population cohorts from multiple continents ????Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=32703421 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32703421 #FOAvip English Wikipedia <ref>{{Cite pmid|32703421}}</ref> Genetic variants that influence SARS-CoV-2 receptor TMPRSS2 expression among population cohorts from multiple continents #MMPMID32703421 Irham LM; Chou WH; Calkins MJ; Adikusuma W; Hsieh SL; Chang WC Biochem Biophys Res Commun 2020[Aug]; 529 (2): 263-269 PMID32703421show ga The World Health Organization recently announced that pandemic status has been achieved for coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Exponential increases in patient numbers have been reported around the world, along with proportional increases in the number of COVID-19-related deaths. The SARS-CoV-2 infection rate in a population is expected to be influenced by social practices, availability of vaccines or prophylactics, and the prevalence of susceptibility genes in the population. Previous work revealed that cellular uptake of SARS-CoV-2 requires Angiotensin Converting Enzyme 2 (ACE-2) and a cellular protease. The spike (S) protein on SARS-CoV-2 binds ACE-2, which functions as an entry receptor. Following receptor binding, transmembrane protease serine 2 (encoded by TMPRSS2) primes the S protein to allow cellular uptake. Therefore, individual expression of TMPRSS2 may be a crucial determinant of SARS-CoV-2 infection susceptibility. Here, we utilized multiple large genome databases, including the GTEx portal, SNP nexus, and Ensembl genome project, to identify gene expression profiles for TMPRSS2 and its important expression quantitative trait loci. Our results show that four variants (rs464397, rs469390, rs2070788 and rs383510) affect expression of TMPRSS2 in lung tissue. The allele frequency of each variant was then assessed in regional populations, including African, American, European, and three Asian cohorts (China, Japan and Taiwan). Interestingly, our data shows that TMPRSS2-upregulating variants are at higher frequencies in European and American populations than in the Asian populations, which implies that these populations might be relatively susceptible to SARS-CoV-2 infection. |*Internationality[MESH] |Asia/ethnology[MESH] |Betacoronavirus/*metabolism[MESH] |Cohort Studies[MESH] |Europe/ethnology[MESH] |Gene Expression Regulation/*genetics[MESH] |Gene Frequency[MESH] |Genetics, Population[MESH] |Geographic Mapping[MESH] |Humans[MESH] |Lung/*metabolism[MESH] |Organ Specificity/genetics[MESH] |Polymorphism, Single Nucleotide[MESH] |Quantitative Trait Loci/genetics[MESH] |Receptors, Virus/*genetics[MESH] |SARS-CoV-2[MESH] |Serine Endopeptidases/*genetics[MESH] |United States/ethnology[MESH]Genetic variants that influence SARS-CoV-2 receptor TMPRSS2 expression(epmc).pdf DeepDyve Pubget Overpricing