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10.1017/S0007114520002913

http://scihub22266oqcxt.onion/10.1017/S0007114520002913
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32703328!7431858!32703328
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suck abstract from ncbi


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pmid32703328      Br+J+Nutr 2021 ; 125 (3): 275-293
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  • The rationale for a multi-step therapeutic approach based on antivirals, drugs and nutrients with immunomodulatory activity in patients with coronavirus-SARS2-induced disease of different severities #MMPMID32703328
  • Fiorino S; Zippi M; Gallo C; Sifo D; Sabbatani S; Manfredi R; Rasciti E; Rasciti L; Giampieri E; Corazza I; Leandri P; de Biase D
  • Br J Nutr 2021[Feb]; 125 (3): 275-293 PMID32703328show ga
  • In December 2019, a novel human-infecting coronavirus, named Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2), was recognised to cause a pneumonia epidemic outbreak with different degrees of severity in Wuhan, Hubei Province in China. Since then, this epidemic has spread worldwide; in Europe, Italy has been involved. Effective preventive and therapeutic strategies are absolutely required to block this serious public health concern. Unfortunately, few studies about SARS-CoV-2 concerning its immunopathogenesis and treatment are available. On the basis of the assumption that the SARS-CoV-2 is genetically related to SARS-CoV (about 82 % of genome homology) and that its characteristics, like the modality of transmission or the type of the immune response it may stimulate, are still poorly known, a literature search was performed to identify the reports assessing these elements in patients with SARS-CoV-induced infection. Therefore, we have analysed: (1) the structure of SARS-CoV-2 and SARS-CoV; (2) the clinical signs and symptoms and pathogenic mechanisms observed during the development of acute respiratory syndrome and the cytokine release syndrome; (3) the modification of the cell microRNome and of the immune response in patients with SARS infection; and (4) the possible role of some fat-soluble compounds (such as vitamins A, D and E) in modulating directly or indirectly the replication ability of SARS-CoV-2 and host immune response.
  • |*SARS-CoV-2[MESH]
  • |Antiviral Agents/*therapeutic use[MESH]
  • |COVID-19/*therapy/*virology[MESH]
  • |Gene Expression Regulation, Viral/drug effects/physiology[MESH]
  • |Genome, Viral[MESH]
  • |Humans[MESH]
  • |Immunologic Factors/*therapeutic use[MESH]
  • |Severe Acute Malnutrition/drug therapy/etiology[MESH]
  • |Severity of Illness Index[MESH]
  • |Viral Proteins[MESH]


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