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10.21203/rs.3.rs-27220/v1

http://scihub22266oqcxt.onion/10.21203/rs.3.rs-27220/v1
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32702737!7336706!32702737
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suck abstract from ncbi


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pmid32702737      Res+Sq 2020 ; ä (ä): ä
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  • B cell clonal expansion and convergent antibody responses to SARS-CoV-2 #MMPMID32702737
  • Nielsen SCA; Yang F; Hoh RA; Jackson KJL; Roeltgen K; Lee JY; Rustagi A; Rogers AJ; Powell AE; Kim PS; Wang TT; Pinsky B; Blish CA; Boyd SD
  • Res Sq 2020[May]; ä (ä): ä PMID32702737show ga
  • During virus infection B cells are critical for the production of antibodies and protective immunity. Establishment of a diverse antibody repertoire occurs by rearrangement of germline DNA at the immunoglobulin heavy and light chain loci to encode the membrane-bound form of antibodies, the B cell antigen receptor. Little is known about the B cells and antigen receptors stimulated by the novel human coronavirus SARS-CoV-2. Here we show that the human B cell compartment in patients with diagnostically confirmed SARS-CoV-2 and clinical COVID-19 is rapidly altered with the early recruitment of B cells expressing a limited subset of V genes, and extensive activation of IgG and IgA subclasses without significant somatic mutation. We detect expansion of B cell clones as well as convergent antibodies with highly similar sequences across SARS-CoV-2 patients, highlighting stereotyped naive responses to this virus. A shared convergent B cell clonotype in SARS-CoV-2 infected patients was previously seen in patients with SARS. These findings offer molecular insights into shared features of human B cell responses to SARS-CoV-2 and other zoonotic spillover coronaviruses.
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