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10.21203/rs.3.rs-30363/v1 http://scihub22266oqcxt.onion/10.21203/rs.3.rs-30363/v1 32702734!7336709!32702734     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Res+Sq 2020 ; ä (ä): ä Nephropedia Template TP {{tp|p=32702734|t=2020. Potentially repurposable drugs for COVID-19 identified from SARS-CoV-2 Host Protein Interactome |pdf=|usr=}}{{32702734}} gab.com Text Potentially repurposable drugs for COVID-19 identified from SARS-CoV-2 Host Protein Interactome JO: Res Sq http://www.kidney.de/pget.php?&tw=1&pmid=32702734 #FOAvip We previously presented the protein-protein interaction network - the 'HoP' or the host protein interactome - of 332 host proteins that were identified to interact with 27 nCoV19 viral proteins by Gordon et al. Here, we studied drugs targeting the proteins in this interactome to identify whether any of them may potentially be repurposable against SARS-CoV-2. We studied each of the drugs using the BaseSpace Correlation Engine and identified those that induce gene expression profiles negatively correlated with SARS-associated expression profile. This analysis resulted in 20 drugs whose differential gene expression (drug versus normal) had an anti-correlation with differential expression for SARS (viral infection versus normal). These included drugs that were already being tested for their clinical activity against SARS-CoV-2, those with proven activity against SARS-CoV/MERS-CoV, broad-spectrum antiviral drugs, and those identified/prioritized by other computational re-purposing studies. In summary, our integrated computational analysis of the HoP interactome in conjunction with drug-induced transcriptomic data resulted in drugs that may be repurposable for COVID-19. Twit Text FOAVip Potentially repurposable drugs for COVID-19 identified from SARS-CoV-2 Host Protein Interactome ????Res Sq http://www.kidney.de/pget.php?&tw=1&pmid=32702734 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32702734 #FOAvip English Wikipedia <ref>{{Cite pmid|32702734}}</ref> Potentially repurposable drugs for COVID-19 identified from SARS-CoV-2 Host Protein Interactome #MMPMID32702734 Karunakaran KB; Balakrishnan N; Ganapathiraju M Res Sq 2020[May]; ä (ä): ä PMID32702734show ga We previously presented the protein-protein interaction network - the 'HoP' or the host protein interactome - of 332 host proteins that were identified to interact with 27 nCoV19 viral proteins by Gordon et al. Here, we studied drugs targeting the proteins in this interactome to identify whether any of them may potentially be repurposable against SARS-CoV-2. We studied each of the drugs using the BaseSpace Correlation Engine and identified those that induce gene expression profiles negatively correlated with SARS-associated expression profile. This analysis resulted in 20 drugs whose differential gene expression (drug versus normal) had an anti-correlation with differential expression for SARS (viral infection versus normal). These included drugs that were already being tested for their clinical activity against SARS-CoV-2, those with proven activity against SARS-CoV/MERS-CoV, broad-spectrum antiviral drugs, and those identified/prioritized by other computational re-purposing studies. In summary, our integrated computational analysis of the HoP interactome in conjunction with drug-induced transcriptomic data resulted in drugs that may be repurposable for COVID-19. äPotentially repurposable drugs for COVID-19 identified from SARS-CoV-2(epmc).pdf DeepDyve Pubget Overpricing