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10.21203/rs.3.rs-28583/v1

http://scihub22266oqcxt.onion/10.21203/rs.3.rs-28583/v1
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32702723!7336693!32702723
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suck abstract from ncbi


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pmid32702723      Res+Sq 2020 ; ä (ä): ä
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  • Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19 #MMPMID32702723
  • Farhadian S; Glick LR; Vogels CBF; Thomas J; Chiarella J; Casanovas-Massana A; Zhou J; Odio C; Vijayakumar P; Geng B; Fournier J; Bermejo S; Fauver JR; Alpert T; Wyllie AL; Turcotte C; Steinle M; Paczkowski P; Cruz CD; Wilen C; Ko AI; MacKay S; Grubaugh ND; Spudich S; Aoun Barakat L
  • Res Sq 2020[May]; ä (ä): ä PMID32702723show ga
  • BACKGROUND: COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic complications can be the presenting manifestation in a subset of infected patients. CASE PRESENTATION: We describe a 78-year old immunocompromised woman who presented with altered mental status after witnessed seizure-like activity at home. She was found to have SARS-CoV-2 infection and associated neuroinflammation. In this case, we undertake the first detailed analysis of cerebrospinal fluid (CSF) cytokines during COVID-19 infection and find a unique pattern of inflammation in CSF, but no evidence of viral neuroinvasion. CONCLUSION: Our findings suggest that neurologic symptoms such as encephalopathy and seizures may be the initial presentation of COVID-19. Central nervous system inflammation may associate with neurologic manifestations of disease.
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