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COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms #MMPMID32702719
Malone RW; Tisdall P; Fremont-Smith P; Liu Y; Huang XP; White KM; Miorin L; Del Olmo EM; Alon A; Delaforge E; Hennecker CD; Wang G; Pottel J; Smith N; Hall JM; Shapiro G; Mittermaier A; Kruse AC; Garcia-Sastre A; Roth BL; Glasspool-Malone J; Ricke DO
Res Sq 2020[Aug]; ä (ä): ä PMID32702719show ga
SARS-CoV-2 infection is required for COVID-19, but many signs and symptoms of COVID-19 differ from common acute viral diseases. Currently, there are no pre- or post-exposure prophylactic COVID-19 medical countermeasures. Clinical data suggest that famotidine may mitigate COVID-19 disease, but both mechanism of action and rationale for dose selection remain obscure. We explore several plausible avenues of activity including antiviral and host-mediated actions. We propose that the principal famotidine mechanism of action for COVID-19 involves on-target histamine receptor H(2) activity, and that development of clinical COVID-19 involves dysfunctional mast cell activation and histamine release.