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10.1093/infdis/jiaa446

http://scihub22266oqcxt.onion/10.1093/infdis/jiaa446
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32702095!7454684!32702095
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suck abstract from ncbi


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pmid32702095      J+Infect+Dis 2020 ; 222 (7): 1103-1107
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  • Persistent COVID-19 in an Immunocompromised Patient Temporarily Responsive to Two Courses of Remdesivir Therapy #MMPMID32702095
  • Helleberg M; Niemann CU; Moestrup KS; Kirk O; Lebech AM; Lane C; Lundgren J
  • J Infect Dis 2020[Sep]; 222 (7): 1103-1107 PMID32702095show ga
  • The antiviral drug remdesivir has been shown clinically effective for treatment of COVID-19. We here demonstrate suppressive but not curative effect of remdesivir in an immunocompromised patient. A man in his fifties treated with chemoimmunotherapy for chronic lymphocytic leukemia experienced a 9-week course of COVID-19 with high fever and severe viral pneumonia. During two 10-day courses of remdesivir starting 24 and 45 days after fever onset, pneumonia and spiking fevers remitted, but relapsed after discontinuation. Kinetics of temperature, C-reactive protein, and lymphocyte counts mirrored the remitting/relapsing SARS-CoV-2 infection. Combination therapy or longer treatment duration may be needed in immunocompromised patients.
  • |Adenosine Monophosphate/*analogs & derivatives/therapeutic use[MESH]
  • |Alanine/*analogs & derivatives/therapeutic use[MESH]
  • |Antiviral Agents/*therapeutic use[MESH]
  • |Betacoronavirus/*drug effects[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Coronavirus Infections/complications/*drug therapy/virology[MESH]
  • |Fever/drug therapy/virology[MESH]
  • |Humans[MESH]
  • |Immunocompromised Host[MESH]
  • |Leukemia, Lymphocytic, Chronic, B-Cell/*complications/drug therapy[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/complications/*drug therapy/virology[MESH]
  • |SARS-CoV-2[MESH]
  • |Severe Acute Respiratory Syndrome/*drug therapy/virology[MESH]
  • |Time Factors[MESH]


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