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10.1080/1354750X.2020.1797880

http://scihub22266oqcxt.onion/10.1080/1354750X.2020.1797880
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32700561!ä!32700561

suck abstract from ncbi


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pmid32700561      Biomarkers 2020 ; 25 (8): 616-625
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  • Assessment of serum ferritin as a biomarker in COVID-19: bystander or participant? Insights by comparison with other infectious and non-infectious diseases #MMPMID32700561
  • Kappert K; Jahic A; Tauber R
  • Biomarkers 2020[Dec]; 25 (8): 616-625 PMID32700561show ga
  • BACKGROUND: The 2019 coronavirus disease (COVID-19) caused by the SARS-CoV-2 virus has an impact on all aspects of patient care. Serum ferritin generally represents a biomarker of choice when iron deficiency is suspected. However, ferritin is also an acute-phase-protein exhibiting elevated serum concentration in various inflammatory diseases. Here we focus on the role of serum ferritin for diagnostic and clinical management of patients with COVID-19 in comparison with other infectious and non-infectious diseases. METHODS: We examined scientific articles listed in PubMed reporting on ferritin in various infectious and non-infectious diseases. We then compared these results with nine current COVID-19 ferritin reports published in 2020. RESULTS: Several non-infectious, as well as non-COVID-19 infectious diseases, are characterised by a partly dramatic elevation of serum ferritin levels. All COVID-19 studies published between February and May 2020, which documented laboratory serum ferritin, indicate ferritin as a biomarker of COVID-19 severity in hospitalised patients. CONCLUSIONS: Serum ferritin may be considered both a prognostic and stratifying biomarker that can also contribute to therapeutic decision-making concerning patients with COVID-19. It should be emphasised, however, that most scientific reports refer to cohorts in the Asian region. Further validation in other cohorts is urgently required.
  • |Biomarkers/*blood[MESH]
  • |COVID-19/*blood/epidemiology/virology[MESH]
  • |Communicable Diseases/*blood/diagnosis[MESH]
  • |Female[MESH]
  • |Ferritins/*blood[MESH]
  • |Humans[MESH]
  • |Inflammation/*blood/diagnosis[MESH]
  • |Male[MESH]
  • |Pandemics[MESH]
  • |Prognosis[MESH]
  • |SARS-CoV-2/physiology[MESH]


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