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10.1111/febs.15495

http://scihub22266oqcxt.onion/10.1111/febs.15495
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32700398!7404739!32700398
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suck abstract from ncbi


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pmid32700398      FEBS+J 2020 ; 287 (17): 3693-3702
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  • Low plasma 25(OH) vitamin D level is associated with increased risk of COVID-19 infection: an Israeli population-based study #MMPMID32700398
  • Merzon E; Tworowski D; Gorohovski A; Vinker S; Golan Cohen A; Green I; Frenkel-Morgenstern M
  • FEBS J 2020[Sep]; 287 (17): 3693-3702 PMID32700398show ga
  • Vitamin D deficiency is a worldwide pandemic. The aim of this study was to evaluate associations of plasma 25(OH)D levels with the likelihood of coronavirus disease 2019 (COVID-19) infection and hospitalization. The study population included the 14 000 members of Leumit Health Services, who were tested for COVID-19 infection from February 1(st) to April 30(th) , 2020, and who had at least one previous blood test for the plasma 25(OH)D level. 'Suboptimal' or 'low' plasma 25(OH)D level was defined as plasma 25-hydroxyvitamin D, or 25(OH)D, concentration below the level of 30 ng/mL. Of 7807 individuals, 782 (10.02%) were COVID-19-positive, and 7025 (89.98%) COVID-19-negative. The mean plasma vitamin D level was significantly lower among those who tested positive than negative for COVID-19 [19.00 ng/mL (95% confidence interval (CI) 18.41-19.59) vs. 20.55 (95% CI: 20.32-20.78)]. Univariate analysis demonstrated an association between the low plasma 25(OH)D level and increased likelihood of COVID-19 infection [crude odds ratio (OR) of 1.58 (95% CI: 1.24-2.01, P < 0.001)], and of hospitalization due to the SARS-CoV-2 virus [crude OR of 2.09 (95% CI: 1.01-4.30, P < 0.05)]. In multivariate analyses that controlled for demographic variables, and psychiatric and somatic disorders, the adjusted OR of COVID-19 infection [1.45 (95% CI: 1.08-1.95, P < 0.001)] and of hospitalization due to the SARS-CoV-2 virus [1.95 (95% CI: 0.98-4.845, P = 0.061)] were preserved. In the multivariate analyses, age over 50 years, male gender and low-medium socioeconomic status were also positively associated with the risk of COVID-19 infection; age over 50 years was positively associated with the likelihood of hospitalization due to COVID-19. We concluded that low plasma 25(OH)D levels appear to be an independent risk factor for COVID-19 infection and hospitalization.
  • |*Pandemics[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Age Factors[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Body Mass Index[MESH]
  • |COVID-19/blood/complications/*epidemiology/virology[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Female[MESH]
  • |Hospitalization/statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Israel/epidemiology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Odds Ratio[MESH]
  • |Prevalence[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2/*pathogenicity[MESH]
  • |Severity of Illness Index[MESH]
  • |Social Class[MESH]
  • |Vitamin D Deficiency/blood/complications/*epidemiology/virology[MESH]


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