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10.1111/bph.15206

http://scihub22266oqcxt.onion/10.1111/bph.15206
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32700336!7405053!32700336
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suck abstract from ncbi


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pmid32700336      Br+J+Pharmacol 2020 ; 177 (21): 4899-4920
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  • Non-steroidal anti-inflammatory drugs, prostaglandins, and COVID-19 #MMPMID32700336
  • Robb CT; Goepp M; Rossi AG; Yao C
  • Br J Pharmacol 2020[Nov]; 177 (21): 4899-4920 PMID32700336show ga
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the novel coronavirus disease 2019 (COVID-19), a highly pathogenic and sometimes fatal respiratory disease responsible for the current 2020 global pandemic. Presently, there remains no effective vaccine or efficient treatment strategies against COVID-19. Non-steroidal anti-inflammatory drugs (NSAIDs) are medicines very widely used to alleviate fever, pain, and inflammation (common symptoms of COVID-19 patients) through effectively blocking production of prostaglandins (PGs) via inhibition of cyclooxyganase enzymes. PGs can exert either proinflammatory or anti-inflammatory effects depending on the inflammatory scenario. In this review, we survey the potential roles that NSAIDs and PGs may play during SARS-CoV-2 infection and the development and progression of COVID-19. LINKED ARTICLES: This article is part of a themed issue on The Pharmacology of COVID-19. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.21/issuetoc.
  • |Animals[MESH]
  • |Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/pharmacology[MESH]
  • |Betacoronavirus/*isolation & purification[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Coronavirus Infections/*drug therapy/virology[MESH]
  • |Disease Progression[MESH]
  • |Humans[MESH]
  • |Inflammation/drug therapy/virology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy/virology[MESH]
  • |Prostaglandins/administration & dosage/pharmacology[MESH]


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