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10.1007/s43440-020-00132-z http://scihub22266oqcxt.onion/10.1007/s43440-020-00132-z 32700247!7375448!32700247     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pharmacol+Rep 2020 ; 72 (6): 1509-1516 Nephropedia Template TP {{tp|p=32700247|t=2020. Cepharanthine: a review of the antiviral potential of a Japanese-approved alopecia drug in COVID-19 |pdf=|usr=}}{{32700247}} gab.com Text Cepharanthine: a review of the antiviral potential of a Japanese-approved alopecia drug in COVID-19 JO: Pharmacol Rep http://www.kidney.de/pget.php?&tw=1&pmid=32700247 #FOAvip Cepharanthine (CEP) is a naturally occurring alkaloid derived from Stephania cepharantha Hayata and demonstrated to have unique anti-inflammatory, antioxidative, immunomodulating, antiparasitic, and antiviral properties. Its therapeutic potential as an antiviral agent has never been more important than in combating COVID-19 caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) virus. Cepharanthine suppresses nuclear factor-kappa B (NF-kappaB) activation, lipid peroxidation, nitric oxide (NO) production, cytokine production, and expression of cyclooxygenase; all of which are crucial to viral replication and inflammatory response. Against SARS-CoV-2 and homologous viruses, CEP predominantly inhibits viral entry and replication at low doses; and was recently identified as the most potent coronavirus inhibitor among 2406 clinically approved drug repurposing candidates in a preclinical model. This review critically analyzes and consolidates available evidence establishing CEP's potential therapeutic importance as a drug of choice in managing COVID-19 cases. Twit Text FOAVip Cepharanthine: a review of the antiviral potential of a Japanese-approved alopecia drug in COVID-19 ????Pharmacol Rep http://www.kidney.de/pget.php?&tw=1&pmid=32700247 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32700247 #FOAvip English Wikipedia <ref>{{Cite pmid|32700247}}</ref> Cepharanthine: a review of the antiviral potential of a Japanese-approved alopecia drug in COVID-19 #MMPMID32700247 Rogosnitzky M; Okediji P; Koman I Pharmacol Rep 2020[Dec]; 72 (6): 1509-1516 PMID32700247show ga Cepharanthine (CEP) is a naturally occurring alkaloid derived from Stephania cepharantha Hayata and demonstrated to have unique anti-inflammatory, antioxidative, immunomodulating, antiparasitic, and antiviral properties. Its therapeutic potential as an antiviral agent has never been more important than in combating COVID-19 caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) virus. Cepharanthine suppresses nuclear factor-kappa B (NF-kappaB) activation, lipid peroxidation, nitric oxide (NO) production, cytokine production, and expression of cyclooxygenase; all of which are crucial to viral replication and inflammatory response. Against SARS-CoV-2 and homologous viruses, CEP predominantly inhibits viral entry and replication at low doses; and was recently identified as the most potent coronavirus inhibitor among 2406 clinically approved drug repurposing candidates in a preclinical model. This review critically analyzes and consolidates available evidence establishing CEP's potential therapeutic importance as a drug of choice in managing COVID-19 cases. |*COVID-19 Drug Treatment[MESH] |Animals[MESH] |Anti-Inflammatory Agents/pharmacology/therapeutic use[MESH] |Antiviral Agents/pharmacology/*therapeutic use[MESH] |Benzylisoquinolines/pharmacology/*therapeutic use[MESH] |COVID-19/virology[MESH] |Drug Repositioning[MESH] |Humans[MESH] |Inflammation/drug therapy/virology[MESH] |Japan[MESH] |SARS-CoV-2/drug effects/isolation & purification[MESH]Cepharanthine: a review of the antiviral potential of a Japanese-appro(epmc).pdf DeepDyve Pubget Overpricing