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10.1186/s40249-020-00728-w

http://scihub22266oqcxt.onion/10.1186/s40249-020-00728-w
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32698862!7374661!32698862
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suck abstract from ncbi


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pmid32698862      Infect+Dis+Poverty 2020 ; 9 (1): 100
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  • Saliva as a diagnostic specimen for detection of SARS-CoV-2 in suspected patients: a scoping review #MMPMID32698862
  • Fakheran O; Dehghannejad M; Khademi A
  • Infect Dis Poverty 2020[Jul]; 9 (1): 100 PMID32698862show ga
  • BACKGROUND: From the begging months of 2020 a severe acute respiratory syndrome coronavirus (SARS-CoV-2, also called 2019-nCoV) caused a devastating global outbreak. At present, the diagnosis of coronavirus disease 2019 (COVID-19) is made through a nasopharyngeal swab based on reverse transcription polymerase chain reaction (RT-PCR) technique. However, some recent studies suggested the possible role of oral fluids and saliva in the detection of SARS-CoV-2. The purpose of this scoping review is evaluating the available evidence regarding the efficacy of saliva as a diagnostic specimen in COVID-19 patients. METHODS: A systematic literature review of six databases (PubMed, Scopus, The Cochrane Central Register of Controlled Trials [CENTRAL], Science Direct, Web of Science and Google scholar) was carried out without any restrictions on date of publication to identify the reliability of saliva as a diagnostic specimen for detection of SARS-CoV-2 in suspected patients. RESULTS: Nine eligible articles were included in this review based on our described method. All the included studies are based on clinical surveys among patients with confirmed SARS-CoV-2 infection. Most of studies included in this review, reported that there is no statistically significant difference between nasopharyngeal or sputum specimens and saliva samples regarding viral load. CONCLUSIONS: Despite limitations of this study, the findings of this review suggest that the use of self-collected saliva as a non-invasive specimen has proper accuracy and reliability regarding detection of SARS-CoV-2 based on RT-PCR technique.
  • |*Viral Load[MESH]
  • |Betacoronavirus/*isolation & purification[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*diagnosis[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*diagnosis[MESH]
  • |Reproducibility of Results[MESH]
  • |SARS-CoV-2[MESH]


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