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Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Respir+Res 2020 ; 21 (1): 194 Nephropedia Template TP
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Continuously available ratio of SpO(2)/FiO(2) serves as a noninvasive prognostic marker for intensive care patients with COVID-19 #MMPMID32698822
Lu X; Jiang L; Chen T; Wang Y; Zhang B; Hong Y; Wang J; Yan F
Respir Res 2020[Jul]; 21 (1): 194 PMID32698822show ga
RATIONALE: Oxygen saturation to fraction of inspired oxygen ratio (SpO(2)/FiO(2)) has been described as potential predictor of poor outcome for COVID-19, without considering its time-varying behavior though. METHODS: Prognostic value of SpO(2)/FiO(2) was evaluated by jointly modeling the longitudinal responses of SpO(2)/FiO(2) and time-to-event data retrieved from 280 severe and critically ill (intensive care) patients with COVID-19. RESULTS: A sharply decrease of SpO(2)/FiO(2) from the first to second measurement for non-survivors was observed, and a strong association between square root SpO(2)/FiO(2) and mortality risk was demonstrated, with a unit decrease in the marker corresponding to 1.82-fold increase in mortality risk (95% CI: 1.56-2.13). CONCLUSIONS: The current study suggested that SpO(2)/FiO(2) could serve as a non-invasive prognostic marker to facilitate early adjustment for treatment, thus improving overall survival.