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10.1186/s12931-020-01455-4

http://scihub22266oqcxt.onion/10.1186/s12931-020-01455-4
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32698822!7374662!32698822
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suck abstract from ncbi


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pmid32698822      Respir+Res 2020 ; 21 (1): 194
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  • Continuously available ratio of SpO(2)/FiO(2) serves as a noninvasive prognostic marker for intensive care patients with COVID-19 #MMPMID32698822
  • Lu X; Jiang L; Chen T; Wang Y; Zhang B; Hong Y; Wang J; Yan F
  • Respir Res 2020[Jul]; 21 (1): 194 PMID32698822show ga
  • RATIONALE: Oxygen saturation to fraction of inspired oxygen ratio (SpO(2)/FiO(2)) has been described as potential predictor of poor outcome for COVID-19, without considering its time-varying behavior though. METHODS: Prognostic value of SpO(2)/FiO(2) was evaluated by jointly modeling the longitudinal responses of SpO(2)/FiO(2) and time-to-event data retrieved from 280 severe and critically ill (intensive care) patients with COVID-19. RESULTS: A sharply decrease of SpO(2)/FiO(2) from the first to second measurement for non-survivors was observed, and a strong association between square root SpO(2)/FiO(2) and mortality risk was demonstrated, with a unit decrease in the marker corresponding to 1.82-fold increase in mortality risk (95% CI: 1.56-2.13). CONCLUSIONS: The current study suggested that SpO(2)/FiO(2) could serve as a non-invasive prognostic marker to facilitate early adjustment for treatment, thus improving overall survival.
  • |Biomarkers/blood[MESH]
  • |COVID-19[MESH]
  • |China[MESH]
  • |Cohort Studies[MESH]
  • |Coronavirus Infections/*blood/diagnosis/*mortality[MESH]
  • |Critical Care/*methods[MESH]
  • |Critical Illness/*mortality/therapy[MESH]
  • |Female[MESH]
  • |Hospital Mortality/*trends[MESH]
  • |Humans[MESH]
  • |Intensive Care Units[MESH]
  • |Longitudinal Studies[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Oximetry/methods[MESH]
  • |Oxygen Consumption/*physiology[MESH]
  • |Oxygen/blood[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*blood/diagnosis/*mortality[MESH]
  • |Predictive Value of Tests[MESH]


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