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10.4155/fmc-2020-0204 http://scihub22266oqcxt.onion/10.4155/fmc-2020-0204 32698626!7377048!32698626     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32698626&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Future+Med+Chem 2020 ; 12 (19): 1743-1757 Nephropedia Template TP {{tp|p=32698626|t=2020. Anti-COVID drugs: repurposing existing drugs or search for new complex entities, strategies and perspectives |pdf=|usr=}}{{32698626}} gab.com Text Anti-COVID drugs: repurposing existing drugs or search for new complex entities, strategies and perspectives JO: Future Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=32698626 #FOAvip At the end of 2019, a novel virus causing severe acute respiratory syndrome to spread globally. There are currently no effective drugs targeting SARS-CoV-2. In this study, based on the analysis of numerous references and selected methods of computational chemistry, the strategy of integrative structural modification of small molecules with antiviral activity into potential active complex molecules has been presented. Proposed molecules have been designed based on the structure of triterpene oleanolic acid and complemented by structures characteristic of selected anti-COVID therapy assisted drugs. Their pharmaceutical molecular parameters and the preliminary bioactivity were calculated and predicted. The results of the above analyses show that among the designed complex substances there are potential antiviral agents directed mainly on SARS-CoV-2. Twit Text FOAVip Anti-COVID drugs: repurposing existing drugs or search for new complex entities, strategies and perspectives ????Future Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=32698626 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32698626 #FOAvip English Wikipedia <ref>{{Cite pmid|32698626}}</ref> Anti-COVID drugs: repurposing existing drugs or search for new complex entities, strategies and perspectives #MMPMID32698626 Pawelczyk A; Zaprutko L Future Med Chem 2020[Oct]; 12 (19): 1743-1757 PMID32698626show ga At the end of 2019, a novel virus causing severe acute respiratory syndrome to spread globally. There are currently no effective drugs targeting SARS-CoV-2. In this study, based on the analysis of numerous references and selected methods of computational chemistry, the strategy of integrative structural modification of small molecules with antiviral activity into potential active complex molecules has been presented. Proposed molecules have been designed based on the structure of triterpene oleanolic acid and complemented by structures characteristic of selected anti-COVID therapy assisted drugs. Their pharmaceutical molecular parameters and the preliminary bioactivity were calculated and predicted. The results of the above analyses show that among the designed complex substances there are potential antiviral agents directed mainly on SARS-CoV-2. |*Drug Repositioning[MESH] |Antiviral Agents/chemistry/*pharmacology[MESH] |Betacoronavirus/*drug effects[MESH] |COVID-19[MESH] |Cardiovascular Agents/chemistry/pharmacology[MESH] |Coronavirus Infections/*drug therapy[MESH] |Drugs, Chinese Herbal/chemistry/pharmacology[MESH] |Humans[MESH] |Oleanolic Acid/chemistry/pharmacology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy[MESH]Anti-COVID drugs: repurposing existing drugs or search for new complex(epmc).pdf DeepDyve Pubget Overpricing