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10.3390/v12070779 http://scihub22266oqcxt.onion/10.3390/v12070779 32698441!7412213!32698441     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Viruses 2020 ; 12 (7): ä Nephropedia Template TP {{tp|p=32698441|t=2020. Age-Dependent Progression of SARS-CoV-2 Infection in Syrian Hamsters |pdf=|usr=}}{{32698441}} gab.com Text Age-Dependent Progression of SARS-CoV-2 Infection in Syrian Hamsters JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=32698441 #FOAvip In late 2019, an outbreak of a severe respiratory disease caused by an emerging coronavirus, SARS-CoV-2, resulted in high morbidity and mortality in infected humans. Complete understanding of COVID-19, the multi-faceted disease caused by SARS-CoV-2, requires suitable small animal models, as does the development and evaluation of vaccines and antivirals. Since age-dependent differences of COVID-19 were identified in humans, we compared the course of SARS-CoV-2 infection in young and aged Syrian hamsters. We show that virus replication in the upper and lower respiratory tract was independent of the age of the animals. However, older hamsters exhibited more pronounced and consistent weight loss. In situ hybridization in the lungs identified viral RNA in bronchial epithelium, alveolar epithelial cells type I and II, and macrophages. Histopathology revealed clear age-dependent differences, with young hamsters launching earlier and stronger immune cell influx than aged hamsters. The latter developed conspicuous alveolar and perivascular edema, indicating vascular leakage. In contrast, we observed rapid lung recovery at day 14 after infection only in young hamsters. We propose that comparative assessment in young versus aged hamsters of SARS-CoV-2 vaccines and treatments may yield valuable information, as this small-animal model appears to mirror age-dependent differences in human patients. Twit Text FOAVip Age-Dependent Progression of SARS-CoV-2 Infection in Syrian Hamsters ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=32698441 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32698441 #FOAvip English Wikipedia <ref>{{Cite pmid|32698441}}</ref> Age-Dependent Progression of SARS-CoV-2 Infection in Syrian Hamsters #MMPMID32698441 Osterrieder N; Bertzbach LD; Dietert K; Abdelgawad A; Vladimirova D; Kunec D; Hoffmann D; Beer M; Gruber AD; Trimpert J Viruses 2020[Jul]; 12 (7): ä PMID32698441show ga In late 2019, an outbreak of a severe respiratory disease caused by an emerging coronavirus, SARS-CoV-2, resulted in high morbidity and mortality in infected humans. Complete understanding of COVID-19, the multi-faceted disease caused by SARS-CoV-2, requires suitable small animal models, as does the development and evaluation of vaccines and antivirals. Since age-dependent differences of COVID-19 were identified in humans, we compared the course of SARS-CoV-2 infection in young and aged Syrian hamsters. We show that virus replication in the upper and lower respiratory tract was independent of the age of the animals. However, older hamsters exhibited more pronounced and consistent weight loss. In situ hybridization in the lungs identified viral RNA in bronchial epithelium, alveolar epithelial cells type I and II, and macrophages. Histopathology revealed clear age-dependent differences, with young hamsters launching earlier and stronger immune cell influx than aged hamsters. The latter developed conspicuous alveolar and perivascular edema, indicating vascular leakage. In contrast, we observed rapid lung recovery at day 14 after infection only in young hamsters. We propose that comparative assessment in young versus aged hamsters of SARS-CoV-2 vaccines and treatments may yield valuable information, as this small-animal model appears to mirror age-dependent differences in human patients. |*Betacoronavirus/immunology/isolation & purification[MESH] |*Disease Models, Animal[MESH] |Age Factors[MESH] |Animals[MESH] |COVID-19[MESH] |Coronavirus Infections/*etiology[MESH] |Cricetinae[MESH] |Disease Progression[MESH] |Female[MESH] |Lung/virology[MESH] |Male[MESH] |Mesocricetus[MESH] |Pandemics[MESH] |Pneumonia, Viral/*etiology[MESH] |RNA, Viral/analysis[MESH] |SARS-CoV-2[MESH]Age-Dependent Progression of SARS-CoV-2 Infection in Syrian Hamsters (epmc).pdf DeepDyve Pubget Overpricing