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10.3390/ijms21145117 http://scihub22266oqcxt.onion/10.3390/ijms21145117 32698380!7404212!32698380     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2020 ; 21 (14): ä Nephropedia Template TP {{tp|p=32698380|t=2020. Carotid Body and Metabolic Syndrome: Mechanisms and Potential Therapeutic Targets |pdf=|usr=}}{{32698380}} gab.com Text Carotid Body and Metabolic Syndrome: Mechanisms and Potential Therapeutic Targets JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32698380 #FOAvip The carotid body (CB) is responsible for the peripheral chemoreflex by sensing blood gases and pH. The CB also appears to act as a peripheral sensor of metabolites and hormones, regulating the metabolism. CB malfunction induces aberrant chemosensory responses that culminate in the tonic overactivation of the sympathetic nervous system. The sympatho-excitation evoked by CB may contribute to the pathogenesis of metabolic syndrome, inducing systemic hypertension, insulin resistance and sleep-disordered breathing. Several molecular pathways are involved in the modulation of CB activity, and their pharmacological manipulation may lead to overall benefits for cardiometabolic diseases. In this review, we will discuss the role of the CB in the regulation of metabolism and in the pathogenesis of the metabolic dysfunction induced by CB overactivity. We will also explore the potential pharmacological targets in the CB for the treatment of metabolic syndrome. Twit Text FOAVip Carotid Body and Metabolic Syndrome: Mechanisms and Potential Therapeutic Targets ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32698380 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32698380 #FOAvip English Wikipedia <ref>{{Cite pmid|32698380}}</ref> Carotid Body and Metabolic Syndrome: Mechanisms and Potential Therapeutic Targets #MMPMID32698380 Kim LJ; Polotsky VY Int J Mol Sci 2020[Jul]; 21 (14): ä PMID32698380show ga The carotid body (CB) is responsible for the peripheral chemoreflex by sensing blood gases and pH. The CB also appears to act as a peripheral sensor of metabolites and hormones, regulating the metabolism. CB malfunction induces aberrant chemosensory responses that culminate in the tonic overactivation of the sympathetic nervous system. The sympatho-excitation evoked by CB may contribute to the pathogenesis of metabolic syndrome, inducing systemic hypertension, insulin resistance and sleep-disordered breathing. Several molecular pathways are involved in the modulation of CB activity, and their pharmacological manipulation may lead to overall benefits for cardiometabolic diseases. In this review, we will discuss the role of the CB in the regulation of metabolism and in the pathogenesis of the metabolic dysfunction induced by CB overactivity. We will also explore the potential pharmacological targets in the CB for the treatment of metabolic syndrome. |Animals[MESH] |Carotid Body/drug effects/metabolism/*physiopathology[MESH] |Drug Discovery[MESH] |Glucose/metabolism[MESH] |Humans[MESH] |Hypertension/drug therapy/metabolism/physiopathology[MESH] |Hypoxia/drug therapy/metabolism/physiopathology[MESH] |Insulin Resistance[MESH] |Metabolic Syndrome/drug therapy/metabolism/*physiopathology[MESH]Carotid Body and Metabolic Syndrome: Mechanisms and Potential Therapeu(epmc).pdf DeepDyve Pubget Overpricing