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10.1038/s41586-020-2575-3 http://scihub22266oqcxt.onion/10.1038/s41586-020-2575-3 32698190!ä!32698190 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nature 2020 ; 585 (7826): 588-590 Nephropedia Template TP {{tp|p=32698190|t=2020. Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2 |pdf=|usr=}}{{32698190}} gab.com Text Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2 JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=32698190 #FOAvip The coronavirus disease 2019 (COVID-19) pandemic, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been associated with more than 780,000 deaths worldwide (as of 20 August 2020). To develop antiviral interventions quickly, drugs used for the treatment of unrelated diseases are currently being repurposed to treat COVID-19. Chloroquine is an anti-malaria drug that is used for the treatment of COVID-19 as it inhibits the spread of SARS-CoV-2 in the African green monkey kidney-derived cell line Vero(1-3). Here we show that engineered expression of TMPRSS2, a cellular protease that activates SARS-CoV-2 for entry into lung cells(4), renders SARS-CoV-2 infection of Vero cells insensitive to chloroquine. Moreover, we report that chloroquine does not block infection with SARS-CoV-2 in the TMPRSS2-expressing human lung cell line Calu-3. These results indicate that chloroquine targets a pathway for viral activation that is not active in lung cells and is unlikely to protect against the spread of SARS-CoV-2 in and between patients. Twit Text FOAVip Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2 ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=32698190 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32698190 #FOAvip English Wikipedia <ref>{{Cite pmid|32698190}}</ref> Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2 #MMPMID32698190 Hoffmann M; Mosbauer K; Hofmann-Winkler H; Kaul A; Kleine-Weber H; Kruger N; Gassen NC; Muller MA; Drosten C; Pohlmann S Nature 2020[Sep]; 585 (7826): 588-590 PMID32698190show ga The coronavirus disease 2019 (COVID-19) pandemic, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been associated with more than 780,000 deaths worldwide (as of 20 August 2020). To develop antiviral interventions quickly, drugs used for the treatment of unrelated diseases are currently being repurposed to treat COVID-19. Chloroquine is an anti-malaria drug that is used for the treatment of COVID-19 as it inhibits the spread of SARS-CoV-2 in the African green monkey kidney-derived cell line Vero(1-3). Here we show that engineered expression of TMPRSS2, a cellular protease that activates SARS-CoV-2 for entry into lung cells(4), renders SARS-CoV-2 infection of Vero cells insensitive to chloroquine. Moreover, we report that chloroquine does not block infection with SARS-CoV-2 in the TMPRSS2-expressing human lung cell line Calu-3. These results indicate that chloroquine targets a pathway for viral activation that is not active in lung cells and is unlikely to protect against the spread of SARS-CoV-2 in and between patients. |Animals[MESH] |Betacoronavirus/drug effects[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Cell Line[MESH] |Chlorocebus aethiops[MESH] |Chloroquine/*pharmacology/*therapeutic use[MESH] |Coronavirus Infections/*drug therapy/*virology[MESH] |Humans[MESH] |In Vitro Techniques[MESH] |Lung/*cytology/*drug effects/virology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy/*virology[MESH] |SARS-CoV-2[MESH] |Serine Endopeptidases/genetics/metabolism[MESH] |Treatment Failure[MESH] |Vero Cells[MESH]Chloroquine does not inhibit infection of human lung cells with SARS-C(epmc).pdf DeepDyve Pubget Overpricing