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10.1530/EJE-20-0335 http://scihub22266oqcxt.onion/10.1530/EJE-20-0335 32698147!9494315!32698147     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Endocrinol 2020 ; 183 (4): 381-387 Nephropedia Template TP {{tp|p=32698147|t=2020. Thyrotoxicosis in patients with COVID-19: the THYRCOV study |pdf=|usr=}}{{32698147}} gab.com Text Thyrotoxicosis in patients with COVID-19: the THYRCOV study JO: Eur J Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=32698147 #FOAvip OBJECTIVE: This study assessed thyroid function in patients affected by the coronavirus disease-19 (COVID-19), based on the hypothesis that the cytokine storm associated with COVID-19 may influence thyroid function and/or the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may directly act on thyroid cells, such as previously demonstrated for SARS-CoV-1 infection. DESIGN AND METHODS: This single-center study was retrospective and consisted in evaluating thyroid function tests and serum interleukin-6 (IL-6) values in 287 consecutive patients (193 males, median age: 66 years, range: 27-92) hospitalized for COVID-19 in non-intensive care units. RESULTS: Fifty-eight patients (20.2%) were found with thyrotoxicosis (overt in 31 cases), 15 (5.2%) with hypothyroidism (overt in only 2 cases), and 214 (74.6%) with normal thyroid function. Serum thyrotropin (TSH) values were inversely correlated with age of patients (rho -0.27; P < 0.001) and IL-6 (rho -0.41; P < 0.001). In the multivariate analysis, thyrotoxicosis resulted to be significantly associated with higher IL-6 (odds ratio: 3.25, 95% confidence interval: 1.97-5.36; P < 0.001), whereas the association with age of patients was lost (P = 0.09). CONCLUSIONS: This study provides first evidence that COVID-19 may be associated with high risk of thyrotoxicosis in relationship with systemic immune activation induced by the SARS-CoV-2 infection. Twit Text FOAVip Thyrotoxicosis in patients with COVID-19: the THYRCOV study ????Eur J Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=32698147 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32698147 #FOAvip English Wikipedia <ref>{{Cite pmid|32698147}}</ref> Thyrotoxicosis in patients with COVID-19: the THYRCOV study #MMPMID32698147 Lania A; Sandri MT; Cellini M; Mirani M; Lavezzi E; Mazziotti G Eur J Endocrinol 2020[Oct]; 183 (4): 381-387 PMID32698147show ga OBJECTIVE: This study assessed thyroid function in patients affected by the coronavirus disease-19 (COVID-19), based on the hypothesis that the cytokine storm associated with COVID-19 may influence thyroid function and/or the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may directly act on thyroid cells, such as previously demonstrated for SARS-CoV-1 infection. DESIGN AND METHODS: This single-center study was retrospective and consisted in evaluating thyroid function tests and serum interleukin-6 (IL-6) values in 287 consecutive patients (193 males, median age: 66 years, range: 27-92) hospitalized for COVID-19 in non-intensive care units. RESULTS: Fifty-eight patients (20.2%) were found with thyrotoxicosis (overt in 31 cases), 15 (5.2%) with hypothyroidism (overt in only 2 cases), and 214 (74.6%) with normal thyroid function. Serum thyrotropin (TSH) values were inversely correlated with age of patients (rho -0.27; P < 0.001) and IL-6 (rho -0.41; P < 0.001). In the multivariate analysis, thyrotoxicosis resulted to be significantly associated with higher IL-6 (odds ratio: 3.25, 95% confidence interval: 1.97-5.36; P < 0.001), whereas the association with age of patients was lost (P = 0.09). CONCLUSIONS: This study provides first evidence that COVID-19 may be associated with high risk of thyrotoxicosis in relationship with systemic immune activation induced by the SARS-CoV-2 infection. |Adult[MESH] |Age Factors[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Betacoronavirus/*immunology[MESH] |COVID-19[MESH] |Coronavirus Infections/blood/*complications/immunology[MESH] |Cytokines/blood/immunology[MESH] |Female[MESH] |Humans[MESH] |Hypothyroidism/epidemiology/immunology/virology[MESH] |Interleukin-6/blood/immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Odds Ratio[MESH] |Pandemics[MESH] |Pneumonia, Viral/blood/*complications/immunology[MESH] |Retrospective Studies[MESH] |Risk Factors[MESH] |SARS-CoV-2[MESH] |Thyroid Function Tests[MESH] |Thyroid Gland/immunology/virology[MESH] |Thyrotoxicosis/epidemiology/immunology/*virology[MESH]Thyrotoxicosis in patients with COVID-19: the THYRCOV study (epmc).pdf DeepDyve Pubget Overpricing