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10.1016/j.cell.2020.06.043 http://scihub22266oqcxt.onion/10.1016/j.cell.2020.06.043 32697968!7332439!32697968     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2020 ; 182 (4): 812-827.e19 Nephropedia Template TP {{tp|p=32697968|t=2020. Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus |pdf=|usr=}}{{32697968}} gab.com Text Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=32697968 #FOAvip A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic. Dynamic tracking of variant frequencies revealed a recurrent pattern of G614 increase at multiple geographic levels: national, regional, and municipal. The shift occurred even in local epidemics where the original D614 form was well established prior to introduction of the G614 variant. The consistency of this pattern was highly statistically significant, suggesting that the G614 variant may have a fitness advantage. We found that the G614 variant grows to a higher titer as pseudotyped virions. In infected individuals, G614 is associated with lower RT-PCR cycle thresholds, suggestive of higher upper respiratory tract viral loads, but not with increased disease severity. These findings illuminate changes important for a mechanistic understanding of the virus and support continuing surveillance of Spike mutations to aid with development of immunological interventions. Twit Text FOAVip Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=32697968 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32697968 #FOAvip English Wikipedia <ref>{{Cite pmid|32697968}}</ref> Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus #MMPMID32697968 Korber B; Fischer WM; Gnanakaran S; Yoon H; Theiler J; Abfalterer W; Hengartner N; Giorgi EE; Bhattacharya T; Foley B; Hastie KM; Parker MD; Partridge DG; Evans CM; Freeman TM; de Silva TI; McDanal C; Perez LG; Tang H; Moon-Walker A; Whelan SP; LaBranche CC; Saphire EO; Montefiori DC Cell 2020[Aug]; 182 (4): 812-827.e19 PMID32697968show ga A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic. Dynamic tracking of variant frequencies revealed a recurrent pattern of G614 increase at multiple geographic levels: national, regional, and municipal. The shift occurred even in local epidemics where the original D614 form was well established prior to introduction of the G614 variant. The consistency of this pattern was highly statistically significant, suggesting that the G614 variant may have a fitness advantage. We found that the G614 variant grows to a higher titer as pseudotyped virions. In infected individuals, G614 is associated with lower RT-PCR cycle thresholds, suggestive of higher upper respiratory tract viral loads, but not with increased disease severity. These findings illuminate changes important for a mechanistic understanding of the virus and support continuing surveillance of Spike mutations to aid with development of immunological interventions. |Betacoronavirus/*genetics/*pathogenicity[MESH] |COVID-19[MESH] |Coronavirus Infections/epidemiology/physiopathology/*virology[MESH] |Epidemiological Monitoring[MESH] |Genetic Fitness[MESH] |Genetic Variation[MESH] |Geographic Information Systems[MESH] |Hospitalization[MESH] |Humans[MESH] |Pandemics[MESH] |Phylogeny[MESH] |Pneumonia, Viral/epidemiology/physiopathology/*virology[MESH] |Respiratory System/virology[MESH] |SARS-CoV-2[MESH] |Severity of Illness Index[MESH] |Spike Glycoprotein, Coronavirus/*genetics[MESH]Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases In(epmc).pdf DeepDyve Pubget Overpricing