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10.1016/j.cmet.2020.07.007 http://scihub22266oqcxt.onion/10.1016/j.cmet.2020.07.007 32697943!7367032!32697943     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32697943&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Metab 2020 ; 32 (3): 437-446.e5 Nephropedia Template TP {{tp|p=32697943|t=2020. Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1alpha/Glycolysis-Dependent Axis |pdf=|usr=}}{{32697943}} gab.com Text Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1alpha/Glycolysis-Dependent Axis JO: Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=32697943 #FOAvip COVID-19 can result in severe lung injury. It remained to be determined why diabetic individuals with uncontrolled glucose levels are more prone to develop the severe form of COVID-19. The molecular mechanism underlying SARS-CoV-2 infection and what determines the onset of the cytokine storm found in severe COVID-19 patients are unknown. Monocytes and macrophages are the most enriched immune cell types in the lungs of COVID-19 patients and appear to have a central role in the pathogenicity of the disease. These cells adapt their metabolism upon infection and become highly glycolytic, which facilitates SARS-CoV-2 replication. The infection triggers mitochondrial ROS production, which induces stabilization of hypoxia-inducible factor-1alpha (HIF-1alpha) and consequently promotes glycolysis. HIF-1alpha-induced changes in monocyte metabolism by SARS-CoV-2 infection directly inhibit T cell response and reduce epithelial cell survival. Targeting HIF-1a may have great therapeutic potential for the development of novel drugs to treat COVID-19. Twit Text FOAVip Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1alpha/Glycolysis-Dependent Axis ????Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=32697943 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32697943 #FOAvip English Wikipedia <ref>{{Cite pmid|32697943}}</ref> Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1alpha/Glycolysis-Dependent Axis #MMPMID32697943 Codo AC; Davanzo GG; Monteiro LB; de Souza GF; Muraro SP; Virgilio-da-Silva JV; Prodonoff JS; Carregari VC; de Biagi Junior CAO; Crunfli F; Jimenez Restrepo JL; Vendramini PH; Reis-de-Oliveira G; Bispo Dos Santos K; Toledo-Teixeira DA; Parise PL; Martini MC; Marques RE; Carmo HR; Borin A; Coimbra LD; Boldrini VO; Brunetti NS; Vieira AS; Mansour E; Ulaf RG; Bernardes AF; Nunes TA; Ribeiro LC; Palma AC; Agrela MV; Moretti ML; Sposito AC; Pereira FB; Velloso LA; Vinolo MAR; Damasio A; Proenca-Modena JL; Carvalho RF; Mori MA; Martins-de-Souza D; Nakaya HI; Farias AS; Moraes-Vieira PM Cell Metab 2020[Sep]; 32 (3): 437-446.e5 PMID32697943show ga COVID-19 can result in severe lung injury. It remained to be determined why diabetic individuals with uncontrolled glucose levels are more prone to develop the severe form of COVID-19. The molecular mechanism underlying SARS-CoV-2 infection and what determines the onset of the cytokine storm found in severe COVID-19 patients are unknown. Monocytes and macrophages are the most enriched immune cell types in the lungs of COVID-19 patients and appear to have a central role in the pathogenicity of the disease. These cells adapt their metabolism upon infection and become highly glycolytic, which facilitates SARS-CoV-2 replication. The infection triggers mitochondrial ROS production, which induces stabilization of hypoxia-inducible factor-1alpha (HIF-1alpha) and consequently promotes glycolysis. HIF-1alpha-induced changes in monocyte metabolism by SARS-CoV-2 infection directly inhibit T cell response and reduce epithelial cell survival. Targeting HIF-1a may have great therapeutic potential for the development of novel drugs to treat COVID-19. |Adult[MESH] |Betacoronavirus/*physiology[MESH] |Blood Glucose/*metabolism[MESH] |COVID-19[MESH] |Cell Line[MESH] |Coronavirus Infections/*complications/metabolism[MESH] |Diabetes Complications/*complications/metabolism[MESH] |Diabetes Mellitus/metabolism[MESH] |Female[MESH] |Glycolysis[MESH] |Humans[MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism[MESH] |Inflammation/complications/metabolism[MESH] |Male[MESH] |Middle Aged[MESH] |Monocytes/*metabolism/virology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*complications/metabolism[MESH] |Reactive Oxygen Species/metabolism[MESH] |SARS-CoV-2[MESH]Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Respon(epmc).pdf DeepDyve Pubget Overpricing