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10.1111/apt.15962 http://scihub22266oqcxt.onion/10.1111/apt.15962 32697870!7404742!32697870     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Aliment+Pharmacol+Ther 2020 ; 52 (6): 1051-1059 Nephropedia Template TP {{tp|p=32697870|t=2020. The association between markers of liver injury and clinical outcomes in patients with COVID-19 in Wuhan |pdf=|usr=}}{{32697870}} gab.com Text The association between markers of liver injury and clinical outcomes in patients with COVID-19 in Wuhan JO: Aliment Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=32697870 #FOAvip BACKGROUND: The outbreak of coronavirus disease 2019 (COVID-19) is a critical challenge for public health. The effect of COVID-19 on liver injury has not been fully established. AIMS: To evaluate the dynamic changes in liver function and the relationship between liver damage and prognosis in patients with COVID-19. METHODS: Retrospective analysis of clinical data of 675 patients with COVID-19 in Zhongnan Hospital of Wuhan University from January 3 to March 8, 2020. Patients were classified as having normal or abnormal liver function and liver injury. RESULTS: Of 675 patients, 253 (37.5%) had abnormal liver function during hospitalisation, and 52 (7.7%) had liver injury. The dynamic changes of ALT and AST levels were more significant in patients with liver injury and in those who died. AST >3-fold upper limit of normal (ULN) had the highest risk of death and mechanical ventilation. Compared to patients with normal AST levels, mortality and risk of mechanical ventilation significantly increased 19.27-fold (95% confidence interval [CI], 4.89-75.97; P < 0.0001) and 116.72-fold (95% CI, 31.58-431.46; P < 0.0001), respectively, in patients with AST above 3-fold ULN. Increased leucocytes, decreased lymphocytes and female sex were independently associated with liver injury. CONCLUSIONS: The dynamic changes in liver function may have a significant correlation with the severity and prognosis of COVID-19. Increased index of liver injury was closely related to mortality and need for mechanical ventilation. Therefore, these indicators should be closely monitored during hospitalisation. Twit Text FOAVip The association between markers of liver injury and clinical outcomes in patients with COVID-19 in Wuhan ????Aliment Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=32697870 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32697870 #FOAvip English Wikipedia <ref>{{Cite pmid|32697870}}</ref> The association between markers of liver injury and clinical outcomes in patients with COVID-19 in Wuhan #MMPMID32697870 Huang H; Chen S; Li H; Zhou XL; Dai Y; Wu J; Zhang J; Shao L; Yan R; Wang M; Wang J; Tu Y; Ge M Aliment Pharmacol Ther 2020[Sep]; 52 (6): 1051-1059 PMID32697870show ga BACKGROUND: The outbreak of coronavirus disease 2019 (COVID-19) is a critical challenge for public health. The effect of COVID-19 on liver injury has not been fully established. AIMS: To evaluate the dynamic changes in liver function and the relationship between liver damage and prognosis in patients with COVID-19. METHODS: Retrospective analysis of clinical data of 675 patients with COVID-19 in Zhongnan Hospital of Wuhan University from January 3 to March 8, 2020. Patients were classified as having normal or abnormal liver function and liver injury. RESULTS: Of 675 patients, 253 (37.5%) had abnormal liver function during hospitalisation, and 52 (7.7%) had liver injury. The dynamic changes of ALT and AST levels were more significant in patients with liver injury and in those who died. AST >3-fold upper limit of normal (ULN) had the highest risk of death and mechanical ventilation. Compared to patients with normal AST levels, mortality and risk of mechanical ventilation significantly increased 19.27-fold (95% confidence interval [CI], 4.89-75.97; P < 0.0001) and 116.72-fold (95% CI, 31.58-431.46; P < 0.0001), respectively, in patients with AST above 3-fold ULN. Increased leucocytes, decreased lymphocytes and female sex were independently associated with liver injury. CONCLUSIONS: The dynamic changes in liver function may have a significant correlation with the severity and prognosis of COVID-19. Increased index of liver injury was closely related to mortality and need for mechanical ventilation. Therefore, these indicators should be closely monitored during hospitalisation. |*Liver Function Tests[MESH] |Adult[MESH] |Aged[MESH] |Biomarkers[MESH] |COVID-19/*epidemiology/mortality[MESH] |Female[MESH] |Hospitalization[MESH] |Humans[MESH] |Liver Diseases/*epidemiology[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Prognosis[MESH] |Retrospective Studies[MESH] |SARS-CoV-2[MESH]The association between markers of liver injury and clinical outcomes (epmc).pdf DeepDyve Pubget Overpricing