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Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Scand+J+Immunol 2020 ; 92 (6): e12944 Nephropedia Template TP
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Are superantigens the cause of cytokine storm and viral sepsis in severe COVID-19? Observations and hypothesis #MMPMID32697367
Scaglioni V; Soriano ER
Scand J Immunol 2020[Dec]; 92 (6): e12944 PMID32697367show ga
Right now the world is going through an unprecedented pandemic caused by a novel coronavirus. Recent papers pointed out the fatal outcome in most of the severe cases, in which a cytokine storm has been proven to be the cause of a systemic shock, acute respiratory syndrome, multiorgan failure and consequently death. Several explanations have been proposed trying to explain the pathophysiology of the cytokine storm, but viral proteins with a possible superantigen activity as a cause of immune dysregulation have not been addressed. If this hypothesis is proven, a different treatment approach might change the outcome in severe cases.