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10.1111/sji.12944

http://scihub22266oqcxt.onion/10.1111/sji.12944
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32697367!7404497!32697367
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suck abstract from ncbi


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pmid32697367      Scand+J+Immunol 2020 ; 92 (6): e12944
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  • Are superantigens the cause of cytokine storm and viral sepsis in severe COVID-19? Observations and hypothesis #MMPMID32697367
  • Scaglioni V; Soriano ER
  • Scand J Immunol 2020[Dec]; 92 (6): e12944 PMID32697367show ga
  • Right now the world is going through an unprecedented pandemic caused by a novel coronavirus. Recent papers pointed out the fatal outcome in most of the severe cases, in which a cytokine storm has been proven to be the cause of a systemic shock, acute respiratory syndrome, multiorgan failure and consequently death. Several explanations have been proposed trying to explain the pathophysiology of the cytokine storm, but viral proteins with a possible superantigen activity as a cause of immune dysregulation have not been addressed. If this hypothesis is proven, a different treatment approach might change the outcome in severe cases.
  • |Antigen Presentation[MESH]
  • |CD4-Positive T-Lymphocytes/*immunology[MESH]
  • |COVID-19/*immunology[MESH]
  • |Cytokines/metabolism[MESH]
  • |Dendritic Cells/*immunology[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |SARS-CoV-2/*physiology[MESH]
  • |Sepsis/*immunology[MESH]


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