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10.1590/0037-8682-0372-2020

http://scihub22266oqcxt.onion/10.1590/0037-8682-0372-2020
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32696811!7375796!32696811
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suck abstract from ncbi


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pmid32696811      Rev+Soc+Bras+Med+Trop 2020 ; 53 (ä): e20200372
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  • Long-term positive severe acute respiratory syndrome coronavirus 2 ribonucleic acid and therapeutic effect of antivirals in patients with coronavirus disease: Case reports #MMPMID32696811
  • Wei B; Hang X; Xie Y; Zhang Y; Wang J; Cao X; Wu JJ; Wang J
  • Rev Soc Bras Med Trop 2020[]; 53 (ä): e20200372 PMID32696811show ga
  • Coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been declared a pandemic. We herein report four COVID-19 cases with long-term positive viral ribonucleic acid (RNA) for about 61 days. Despite treatment with recombinant human interferon, convalescent plasma from COVID-19 patients, arbidol, etc., nucleic acid results were still positive for SARS-CoV-2. After treatment with ritonavir-boosted danoprevir (DNVr, 100/100 mg, once daily), all four patients showed two to three consecutive negative SARS-CoV-2 RNA and were thus discharged from hospital. Therefore, DNVr may be a potentially effective antiviral for COVID-19 patients with long-term positive SARS-CoV-2 RNA.
  • |*Antiviral Agents/therapeutic use[MESH]
  • |*Coronavirus[MESH]
  • |*Coronavirus Infections/drug therapy/virology[MESH]
  • |*Pandemics[MESH]
  • |*Pneumonia, Viral/drug therapy/virology[MESH]
  • |*RNA, Viral/blood[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]


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