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10.3389/fimmu.2020.01606 http://scihub22266oqcxt.onion/10.3389/fimmu.2020.01606 32695122!7338588!32695122     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32695122&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2020 ; 11 (ä): 1606 Nephropedia Template TP {{tp|p=32695122|t=2020. Deciphering the Role of Host Genetics in Susceptibility to Severe COVID-19 |pdf=|usr=}}{{32695122}} gab.com Text Deciphering the Role of Host Genetics in Susceptibility to Severe COVID-19 JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32695122 #FOAvip Coronavirus disease-19 (COVID-19) describes a set of symptoms that develop following infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Whilst COVID-19 disease is most serious in patients with significant co-morbidities, the reason for healthy individuals succumbing to fulminant infection is largely unexplained. In this review, we discuss the most recent findings in terms of clinical features and the host immune response, and suggest candidate immune pathways that may be compromised in otherwise healthy individuals with fulminating COVID-19. On the basis of this early knowledge we reason a potential genetic effect on host immune response pathways leading to increased susceptibility to SARS-CoV-2 infection. Understanding these pathways may help not only in unraveling disease pathogenesis, but also in suggesting targets for therapy and prophylaxis. Importantly such insight should instruct efforts to identify those at increased risk in order to institute preventative measures, such as prophylactic medication and/or vaccination, when such opportunities arise in the later phases of the current pandemic or during future similar pandemics. Twit Text FOAVip Deciphering the Role of Host Genetics in Susceptibility to Severe COVID-19 ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32695122 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32695122 #FOAvip English Wikipedia <ref>{{Cite pmid|32695122}}</ref> Deciphering the Role of Host Genetics in Susceptibility to Severe COVID-19 #MMPMID32695122 Carter-Timofte ME; Jorgensen SE; Freytag MR; Thomsen MM; Brinck Andersen NS; Al-Mousawi A; Hait AS; Mogensen TH Front Immunol 2020[]; 11 (ä): 1606 PMID32695122show ga Coronavirus disease-19 (COVID-19) describes a set of symptoms that develop following infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Whilst COVID-19 disease is most serious in patients with significant co-morbidities, the reason for healthy individuals succumbing to fulminant infection is largely unexplained. In this review, we discuss the most recent findings in terms of clinical features and the host immune response, and suggest candidate immune pathways that may be compromised in otherwise healthy individuals with fulminating COVID-19. On the basis of this early knowledge we reason a potential genetic effect on host immune response pathways leading to increased susceptibility to SARS-CoV-2 infection. Understanding these pathways may help not only in unraveling disease pathogenesis, but also in suggesting targets for therapy and prophylaxis. Importantly such insight should instruct efforts to identify those at increased risk in order to institute preventative measures, such as prophylactic medication and/or vaccination, when such opportunities arise in the later phases of the current pandemic or during future similar pandemics. |*Betacoronavirus/genetics/immunology[MESH] |*Coronavirus Infections/epidemiology/genetics/immunology[MESH] |*Genetic Predisposition to Disease[MESH] |*Pandemics[MESH] |*Pneumonia, Viral/epidemiology/genetics/immunology[MESH] |COVID-19[MESH] |Humans[MESH] |SARS-CoV-2[MESH]Deciphering the Role of Host Genetics in Susceptibility to Severe COVI(epmc).pdf DeepDyve Pubget Overpricing