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10.3389/fphys.2020.00802 http://scihub22266oqcxt.onion/10.3389/fphys.2020.00802 32695025!7338756!32695025     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32695025&cmd=llinks): Failed to open stream: HTTP request failed! 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Regulatory Cross Talk Between SARS-CoV-2 Receptor Binding and Replication Machinery in the Human Host |pdf=|usr=}}{{32695025}} gab.com Text Regulatory Cross Talk Between SARS-CoV-2 Receptor Binding and Replication Machinery in the Human Host JO: Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=32695025 #FOAvip We dissect the mechanism of SARS-CoV-2 in human lung host from the initial phase of receptor binding to viral replication machinery. Two independent lung protein interactome were constructed to reveal the signaling process on receptor activation and host protein hijacking machinery in the pathogenesis of virus. Further, we test the functional role of the hubs derived from the interactome. Most hubs proteins were differentially regulated on SARS-CoV-2 infection. Also, the proteins in viral replication hubs were related with cardiovascular disease, diabetes and hypertension confirming the vulnerability and severity of infection in the risk individual. Additionally, the hub proteins were closely linked with other viral infection, including MERS and HCoVs which suggest similar infection pattern in SARS-CoV-2. We identified five hubs that interconnect both networks that show the preparation of optimal environment in the host for viral replication process upon receptor attachment. Interestingly, we propose that seven potential miRNAs, targeting the intermediate phase that connects receptor and viral replication process a better choice as a drug for SARS-CoV-2. Twit Text FOAVip Regulatory Cross Talk Between SARS-CoV-2 Receptor Binding and Replication Machinery in the Human Host ????Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=32695025 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32695025 #FOAvip English Wikipedia <ref>{{Cite pmid|32695025}}</ref> Regulatory Cross Talk Between SARS-CoV-2 Receptor Binding and Replication Machinery in the Human Host #MMPMID32695025 Ahmed SSSJ; Paramasivam P; Raj K; Kumar V; Murugesan R; Ramakrishnan V Front Physiol 2020[]; 11 (ä): 802 PMID32695025show ga We dissect the mechanism of SARS-CoV-2 in human lung host from the initial phase of receptor binding to viral replication machinery. Two independent lung protein interactome were constructed to reveal the signaling process on receptor activation and host protein hijacking machinery in the pathogenesis of virus. Further, we test the functional role of the hubs derived from the interactome. Most hubs proteins were differentially regulated on SARS-CoV-2 infection. Also, the proteins in viral replication hubs were related with cardiovascular disease, diabetes and hypertension confirming the vulnerability and severity of infection in the risk individual. Additionally, the hub proteins were closely linked with other viral infection, including MERS and HCoVs which suggest similar infection pattern in SARS-CoV-2. We identified five hubs that interconnect both networks that show the preparation of optimal environment in the host for viral replication process upon receptor attachment. Interestingly, we propose that seven potential miRNAs, targeting the intermediate phase that connects receptor and viral replication process a better choice as a drug for SARS-CoV-2. äRegulatory Cross Talk Between SARS-CoV-2 Receptor Binding and Replicat(epmc).pdf DeepDyve Pubget Overpricing