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10.1097/RHU.0000000000001539

http://scihub22266oqcxt.onion/10.1097/RHU.0000000000001539
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32694358!7437433!32694358
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suck abstract from ncbi


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pmid32694358      J+Clin+Rheumatol 2020 ; 26 (6): 224-228
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  • Hydroxychloroquine and Chloroquine in COVID-19: A Survey of Prescription Patterns Among Rheumatologists #MMPMID32694358
  • Mehta B; Moezinia CJ; Jannat-Khah D; Gibofsky A; Tornberg H; Pearce-Fisher D; Goodman SM; Salmon JE; Ibrahim S
  • J Clin Rheumatol 2020[Sep]; 26 (6): 224-228 PMID32694358show ga
  • OBJECTIVE: With hydroxychloroquine (HCQ) and chloroquine (CQ) emerging as potential therapies for coronavirus disease 2019 (COVID-19), shortages have been reported. We aimed to understand how rheumatologists, one of the most common prescribers of HCQ/CQ, prescribed these medications to manage COVID-19 and to understand if their patients are affected by shortages. METHODS: Between April 8 and April 27, 2020, an online survey was distributed to a convenience sample of rheumatologists who practice medicine in a diverse range of settings globally, resulting in 506 responses. Adjusted Poisson regression models were calculated. RESULTS: Only 6% of respondents prescribed HCQ/CQ for COVID-19 prophylaxis, and only 12% for outpatient treatment of COVID-19. Compared to the United States, the likelihood of prescribing HCQ/CQ for prophylaxis was higher in India (adjusted risk ratio [aRR], 6.7; 95% confidence interval [CI], 2.7-16.8; p < 0.001). Further, compared to the United States and those with 1 to 5 years of experience, rheumatologists in Europe (aRR, 2.9; 95% CI, 1.6-5.3; p < 0.001) and those with 10+ years of experience (11-20 years: aRR, 2.5; 95% CI, 1.2-5.3; p = 0.015; 21+ years: aRR = 3.3; 95% CI, 1.4-7.4; p = 0.004) had a higher likelihood of prescribing HCQ/CQ for outpatient treatment. Of note, 71% of all rheumatologists reported that their patients were directly affected by HCQ/CQ shortages. CONCLUSION: The results suggest that only a small percentage of rheumatologists are prescribing HCQ/CQ for prophylaxis or outpatient treatment of COVID-19. Medication shortages experienced by large numbers of autoimmune disease patients are concerning and should play a role in decisions, especially given poor efficacy data for HCQ/CQ in COVID-19.
  • |*Betacoronavirus[MESH]
  • |*Rheumatology[MESH]
  • |Antirheumatic Agents/therapeutic use[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Coronavirus Infections/drug therapy/epidemiology/*prevention & control[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/*therapeutic use[MESH]
  • |Male[MESH]
  • |Pandemics/*prevention & control[MESH]
  • |Pneumonia, Viral/epidemiology/*prevention & control[MESH]
  • |Practice Patterns, Physicians'/*statistics & numerical data[MESH]
  • |SARS-CoV-2[MESH]


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