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10.7861/clinmed.2020-0346

http://scihub22266oqcxt.onion/10.7861/clinmed.2020-0346
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32694169!7539718!32694169
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suck abstract from ncbi


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pmid32694169      Clin+Med+(Lond) 2020 ; 20 (5): e178-e182
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  • Von Willebrand factor (vWF): marker of endothelial damage and thrombotic risk in COVID-19? #MMPMID32694169
  • Ladikou EE; Sivaloganathan H; Milne KM; Arter WE; Ramasamy R; Saad R; Stoneham SM; Philips B; Eziefula AC; Chevassut T
  • Clin Med (Lond) 2020[Sep]; 20 (5): e178-e182 PMID32694169show ga
  • BACKGROUND: COVID-19 infection is characterised, among other features, by a prothrombotic state with high rate of venous thromboembolism (VTE), D-dimer, and fibrinogen levels. Clinical observations have also highlighted that these patients have elevated von Willebrand factor (vWF) and factor VIIIc. METHODS: 24 consecutive COVID-19 positive patients were selected from the intensive care unit (ICU) or the high acuity ward of Brighton and Sussex University Hospitals NHS Trust. RESULTS: The rate of VTE was 25% and mortality rate was 16.7%. Fibrinogen and D-Dimers were elevated, 7.9 (1.6) g/L and 2.4 (2.02) ug/ml respectively. Factor VIIIc and von vWF antigen levels were both extremely elevated at 279 (148) u/dL and 350 (131) % respectively, which are comparable to levels seen in ICU patients with severe sepsis. vWF levels were significantly higher in patients that died (p=0.017) and showed a positive correlation with age. There was a statistically significant association between COVID-19 disease and non-O blood group (p=0.02); 80% (4/5) of COVID-19 patients with VTE were blood group A. CONCLUSION: Very high levels of vWF and factor VIIIc are common in COVID-19 patients, comparable to levels in severely septic non-COVID ICU patients. This could contribute to the hypercoagulable state and increased VTE rate in COVID-19. Further studies are needed to evaluate the use of vWF for stratifying thrombotic risk in COVID-19 and to determine if elevated vWF is contributing to disease pathogenesis.
  • |Biomarkers/blood[MESH]
  • |COVID-19[MESH]
  • |Cohort Studies[MESH]
  • |Coronavirus Infections/*complications/diagnosis/mortality[MESH]
  • |Endothelium, Vascular/*pathology[MESH]
  • |Female[MESH]
  • |Fibrin Fibrinogen Degradation Products/metabolism[MESH]
  • |Fibrinogen/metabolism[MESH]
  • |Hospital Mortality/*trends[MESH]
  • |Hospitals, University[MESH]
  • |Humans[MESH]
  • |Intensive Care Units[MESH]
  • |Male[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*complications/diagnosis/mortality[MESH]
  • |Risk Assessment[MESH]
  • |Sampling Studies[MESH]
  • |Severe Acute Respiratory Syndrome/*blood/diagnosis[MESH]
  • |Survival Rate[MESH]
  • |United Kingdom[MESH]
  • |Venous Thromboembolism/blood/*etiology/mortality[MESH]


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