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10.1016/j.ejmech.2020.112653

http://scihub22266oqcxt.onion/10.1016/j.ejmech.2020.112653
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suck abstract from ncbi


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pmid32693294      Eur+J+Med+Chem 2020 ; 203 (ä): 112653
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  • Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses #MMPMID32693294
  • Nebigil CG; Moog C; Vagner S; Benkirane-Jessel N; Smith DR; Desaubry L
  • Eur J Med Chem 2020[Oct]; 203 (ä): 112653 PMID32693294show ga
  • Flavaglines are cyclopenta[b]benzofurans found in plants of the genus Aglaia, several species of which are used in traditional Chinese medicine. These compounds target the initiation factor of translation eIF4A and the scaffold proteins prohibitins-1 and 2 (PHB1/2) to exert various pharmacological activities, including antiviral effects against several types of viruses, including coronaviruses. This review is focused on the antiviral effects of flavaglines and their therapeutic potential against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
  • |Aglaia/*chemistry[MESH]
  • |Animals[MESH]
  • |Antiviral Agents/*therapeutic use[MESH]
  • |Biological Products/*therapeutic use[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*drug therapy[MESH]
  • |Eukaryotic Initiation Factor-4A/drug effects/*genetics[MESH]
  • |Humans[MESH]
  • |Medicine, Chinese Traditional[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy[MESH]
  • |Prohibitins[MESH]


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