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suck abstract from ncbi


10.1016/j.ijbiomac.2020.07.174

http://scihub22266oqcxt.onion/10.1016/j.ijbiomac.2020.07.174
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32693122!7368152!32693122
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suck abstract from ncbi


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pmid32693122      Int+J+Biol+Macromol 2020 ; 164 (ä): 66-76
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  • A molecular docking study revealed that synthetic peptides induced conformational changes in the structure of SARS-CoV-2 spike glycoprotein, disrupting the interaction with human ACE2 receptor #MMPMID32693122
  • Souza PFN; Lopes FES; Amaral JL; Freitas CDT; Oliveira JTA
  • Int J Biol Macromol 2020[Dec]; 164 (ä): 66-76 PMID32693122show ga
  • The global outbreak of COVID-19 (Coronavirus Disease 2019) caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome caused by Coronavirus 2) began in December 2019. Its closest relative, SARS-CoV-1, has a slightly mutated Spike (S) protein, which interacts with ACE2 receptor in human cells to start the infection. So far, there are no vaccines or drugs to treat COVID-19. So, research groups worldwide are seeking new molecules targeting the S protein to prevent infection by SARS-CoV-2 and COVID-19 establishment. We performed molecular docking analysis of eight synthetic peptides against SARS-CoV-2 S protein. All interacted with the protein, but Mo-CBP(3)-PepII and PepKAA had the highest affinity with it. By binding to the S protein, both peptides led to conformational alterations in the protein, resulting in incorrect interaction with ACE2. Therefore, given the importance of the S protein-ACE2 interaction for SARS-CoV-2 infection, synthetic peptides could block SARS-CoV-2 infection. Moreover, unlike other antiviral drugs, peptides have no toxicity to human cells. Thus, these peptides are potential molecules to be tested against SARS-CoV-2 and to develop new drugs to treat COVID-19.
  • |Angiotensin-Converting Enzyme 2[MESH]
  • |Antiviral Agents/chemistry/*pharmacology[MESH]
  • |Betacoronavirus/*chemistry/drug effects/metabolism[MESH]
  • |Binding Sites/drug effects[MESH]
  • |COVID-19[MESH]
  • |Computational Biology[MESH]
  • |Coronavirus Infections/*drug therapy/metabolism/virology[MESH]
  • |Humans[MESH]
  • |Molecular Docking Simulation[MESH]
  • |Pandemics[MESH]
  • |Peptides/chemistry/*pharmacology[MESH]
  • |Peptidyl-Dipeptidase A/*chemistry/metabolism[MESH]
  • |Pneumonia, Viral/*drug therapy/metabolism/virology[MESH]
  • |Protein Binding/drug effects[MESH]
  • |Protein Conformation/drug effects[MESH]
  • |Protein Interaction Domains and Motifs/drug effects[MESH]
  • |SARS-CoV-2[MESH]


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