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10.1111/bcp.14489 http://scihub22266oqcxt.onion/10.1111/bcp.14489 32692462!ä!32692462 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Clin+Pharmacol 2021 ; 87 (3): 1547-1553 Nephropedia Template TP {{tp|p=32692462|t=2021. Abnormal laboratory findings and plasma concentration monitoring of lopinavir and ritonavir in COVID-19 |pdf=|usr=}}{{32692462}} gab.com Text Abnormal laboratory findings and plasma concentration monitoring of lopinavir and ritonavir in COVID-19 JO: Br J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32692462 #FOAvip It is not known whether the adverse events (AEs) associated with the administration of lopinavir and ritonavir (LPV/r) in the treatment of COVID-19 are concentration-dependent. In a retrospective study of 65 patients treated with LPV/r and therapeutic drug monitoring (TDM) for severe forms of COVID-19 (median age: 67; males: 41 [63.1%]), 33 (50.8%) displayed a grade >/=2 increase in plasma levels of hepatobiliary markers, lipase and/or triglycerides. A causal relationship between LPV/r and the AE was suspected in 9 of the 65 patients (13.8%). At 400 mg b.i.d., the plasma trough concentrations of LPV/r were high and showed marked interindividual variability (median [interquartile range]: 16,600 [11,430-20,842] ng/ml for lopinavir and 501 [247-891] ng/ml for ritonavir). The trough lopinavir concentration was negatively correlated with body mass index, while the trough ritonavir concentration was positively correlated with age and negatively correlated with prothrombin activity. However, the occurrence of abnormal laboratory values was not associated with higher trough plasma concentrations of LPV/r. Further studies will be needed to determine the value of TDM in LPV/r-treated patients with COVID-19. Twit Text FOAVip Abnormal laboratory findings and plasma concentration monitoring of lopinavir and ritonavir in COVID-19 ????Br J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32692462 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32692462 #FOAvip English Wikipedia <ref>{{Cite pmid|32692462}}</ref> Abnormal laboratory findings and plasma concentration monitoring of lopinavir and ritonavir in COVID-19 #MMPMID32692462 Batteux B; Bodeau S; Gras-Champel V; Liabeuf S; Lanoix JP; Schmit JL; Andrejak C; Zerbib Y; Haye G; Masmoudi K; Lemaire-Hurtel AS; Bennis Y Br J Clin Pharmacol 2021[Mar]; 87 (3): 1547-1553 PMID32692462show ga It is not known whether the adverse events (AEs) associated with the administration of lopinavir and ritonavir (LPV/r) in the treatment of COVID-19 are concentration-dependent. In a retrospective study of 65 patients treated with LPV/r and therapeutic drug monitoring (TDM) for severe forms of COVID-19 (median age: 67; males: 41 [63.1%]), 33 (50.8%) displayed a grade >/=2 increase in plasma levels of hepatobiliary markers, lipase and/or triglycerides. A causal relationship between LPV/r and the AE was suspected in 9 of the 65 patients (13.8%). At 400 mg b.i.d., the plasma trough concentrations of LPV/r were high and showed marked interindividual variability (median [interquartile range]: 16,600 [11,430-20,842] ng/ml for lopinavir and 501 [247-891] ng/ml for ritonavir). The trough lopinavir concentration was negatively correlated with body mass index, while the trough ritonavir concentration was positively correlated with age and negatively correlated with prothrombin activity. However, the occurrence of abnormal laboratory values was not associated with higher trough plasma concentrations of LPV/r. Further studies will be needed to determine the value of TDM in LPV/r-treated patients with COVID-19. |Aged[MESH] |Aged, 80 and over[MESH] |Aging/metabolism[MESH] |Anti-Retroviral Agents/*adverse effects/*blood/therapeutic use[MESH] |Body Mass Index[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/*blood[MESH] |Female[MESH] |Humans[MESH] |Lopinavir/*adverse effects/*blood/therapeutic use[MESH] |Male[MESH] |Middle Aged[MESH] |Prothrombin/analysis[MESH] |Retrospective Studies[MESH]Abnormal laboratory findings and plasma concentration monitoring of lo(epmc).pdf DeepDyve Pubget Overpricing