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10.1093/infdis/jiaa392 http://scihub22266oqcxt.onion/10.1093/infdis/jiaa392 32692346!7454749!32692346     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32692346&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Infect+Dis 2021 ; 223 (3): 409-415 Nephropedia Template TP {{tp|p=32692346|t=2021. Direct Observation of Repeated Infections With Endemic Coronaviruses |pdf=|usr=}}{{32692346}} gab.com Text Direct Observation of Repeated Infections With Endemic Coronaviruses JO: J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=32692346 #FOAvip BACKGROUND: Although the mechanisms of adaptive immunity to pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are still unknown, the immune response to the widespread endemic coronaviruses HKU1, 229E, NL63, and OC43 provide a useful reference for understanding repeat infection risk. METHODS: Here we used data from proactive sampling carried out in New York City from fall 2016 to spring 2018. We combined weekly nasal swab collection with self-reports of respiratory symptoms from 191 participants to investigate the profile of recurring infections with endemic coronaviruses. RESULTS: During the study, 12 individuals tested positive multiple times for the same coronavirus. We found no significant difference between the probability of testing positive at least once and the probability of a recurrence for the betacoronaviruses HKU1 and OC43 at 34 weeks after enrollment/first infection. We also found no significant association between repeat infections and symptom severity, but found strong association between symptom severity and belonging to the same family. CONCLUSIONS: This study provides evidence that reinfections with the same endemic coronavirus are not atypical in a time window shorter than 1 year and that the genetic basis of innate immune response may be a greater determinant of infection severity than immune memory acquired after a previous infection. Twit Text FOAVip Direct Observation of Repeated Infections With Endemic Coronaviruses ????J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=32692346 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32692346 #FOAvip English Wikipedia <ref>{{Cite pmid|32692346}}</ref> Direct Observation of Repeated Infections With Endemic Coronaviruses #MMPMID32692346 Galanti M; Shaman J J Infect Dis 2021[Feb]; 223 (3): 409-415 PMID32692346show ga BACKGROUND: Although the mechanisms of adaptive immunity to pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are still unknown, the immune response to the widespread endemic coronaviruses HKU1, 229E, NL63, and OC43 provide a useful reference for understanding repeat infection risk. METHODS: Here we used data from proactive sampling carried out in New York City from fall 2016 to spring 2018. We combined weekly nasal swab collection with self-reports of respiratory symptoms from 191 participants to investigate the profile of recurring infections with endemic coronaviruses. RESULTS: During the study, 12 individuals tested positive multiple times for the same coronavirus. We found no significant difference between the probability of testing positive at least once and the probability of a recurrence for the betacoronaviruses HKU1 and OC43 at 34 weeks after enrollment/first infection. We also found no significant association between repeat infections and symptom severity, but found strong association between symptom severity and belonging to the same family. CONCLUSIONS: This study provides evidence that reinfections with the same endemic coronavirus are not atypical in a time window shorter than 1 year and that the genetic basis of innate immune response may be a greater determinant of infection severity than immune memory acquired after a previous infection. |Adult[MESH] |Betacoronavirus[MESH] |COVID-19/epidemiology/immunology[MESH] |Coronavirus Infections/diagnostic imaging/*epidemiology/*virology[MESH] |Coronavirus/genetics/*isolation & purification[MESH] |Endemic Diseases[MESH] |Humans[MESH] |Immunity, Innate[MESH] |New York City/epidemiology[MESH] |Respiratory Tract Infections/diagnostic imaging/epidemiology/virology[MESH] |SARS-CoV-2[MESH]Direct Observation of Repeated Infections With Endemic Coronaviruses (epmc).pdf DeepDyve Pubget Overpricing