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10.1002/jmv.26319 http://scihub22266oqcxt.onion/10.1002/jmv.26319 32691890!7404937!32691890     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Med+Virol 2021 ; 93 (2): 863-869 Nephropedia Template TP {{tp|p=32691890|t=2021. ACE2, TMPRSS2, and Furin variants and SARS-CoV-2 infection in Madrid, Spain |pdf=|usr=}}{{32691890}} gab.com Text ACE2, TMPRSS2, and Furin variants and SARS-CoV-2 infection in Madrid, Spain JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32691890 #FOAvip It has been suggested that some individuals may present genetic susceptibility to SARS-CoV-2 infection, with particular research interest in variants of the ACE2 and TMPRSS2 genes, involved in viral penetration into cells, in different populations and geographic regions, although insufficient information is currently available. This study addresses the apparently reasonable hypothesis that variants of these genes may modulate viral infectivity, making some individuals more vulnerable than others. Through whole-exome sequencing, the frequency of exonic variants of the ACE2, TMPRSS2, and Furin genes was analyzed in relation to presence or absence of SARS-CoV-2 infection in a familial multiple sclerosis cohort including 120 individuals from Madrid. The ACE2 gene showed a low level of polymorphism, and none variant was significantly associated with SARS-CoV-2 infection. These variants have previously been detected in Italy. While TMPRSS2 is highly polymorphic, the variants found do not coincide with those described in other studies, with the exception of rs75603675, which may be associated with SARS-CoV-2 infection. The synonymous variants rs61735792 and rs61735794 showed a significant association with infection. Despite the limited number of patients with SARS-CoV-2 infection, some variants, especially in TMPRSS2, may be associated with COVID-19. Twit Text FOAVip ACE2, TMPRSS2, and Furin variants and SARS-CoV-2 infection in Madrid, Spain ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32691890 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32691890 #FOAvip English Wikipedia <ref>{{Cite pmid|32691890}}</ref> ACE2, TMPRSS2, and Furin variants and SARS-CoV-2 infection in Madrid, Spain #MMPMID32691890 Torre-Fuentes L; Matias-Guiu J; Hernandez-Lorenzo L; Montero-Escribano P; Pytel V; Porta-Etessam J; Gomez-Pinedo U; Matias-Guiu JA J Med Virol 2021[Feb]; 93 (2): 863-869 PMID32691890show ga It has been suggested that some individuals may present genetic susceptibility to SARS-CoV-2 infection, with particular research interest in variants of the ACE2 and TMPRSS2 genes, involved in viral penetration into cells, in different populations and geographic regions, although insufficient information is currently available. This study addresses the apparently reasonable hypothesis that variants of these genes may modulate viral infectivity, making some individuals more vulnerable than others. Through whole-exome sequencing, the frequency of exonic variants of the ACE2, TMPRSS2, and Furin genes was analyzed in relation to presence or absence of SARS-CoV-2 infection in a familial multiple sclerosis cohort including 120 individuals from Madrid. The ACE2 gene showed a low level of polymorphism, and none variant was significantly associated with SARS-CoV-2 infection. These variants have previously been detected in Italy. While TMPRSS2 is highly polymorphic, the variants found do not coincide with those described in other studies, with the exception of rs75603675, which may be associated with SARS-CoV-2 infection. The synonymous variants rs61735792 and rs61735794 showed a significant association with infection. Despite the limited number of patients with SARS-CoV-2 infection, some variants, especially in TMPRSS2, may be associated with COVID-19. |Angiotensin-Converting Enzyme 2/*genetics/metabolism[MESH] |COVID-19/*genetics/metabolism/virology[MESH] |Cohort Studies[MESH] |Exome Sequencing[MESH] |Furin/*genetics/metabolism[MESH] |Gene Expression[MESH] |Genetic Predisposition to Disease[MESH] |Host-Pathogen Interactions/genetics[MESH] |Humans[MESH] |Multiple Sclerosis/*genetics/metabolism/virology[MESH] |Polymorphism, Genetic[MESH] |Protein Binding[MESH] |Receptors, Virus/*genetics/metabolism[MESH] |SARS-CoV-2/genetics/metabolism/pathogenicity[MESH] |Serine Endopeptidases/*genetics/metabolism[MESH] |Spain[MESH] |Spike Glycoprotein, Coronavirus/genetics/metabolism[MESH] |Surveys and Questionnaires[MESH]ACE2, TMPRSS2, and Furin variants and SARS-CoV-2 infection in Madrid, (epmc).pdf DeepDyve Pubget Overpricing