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10.1093/ofid/ofaa219

http://scihub22266oqcxt.onion/10.1093/ofid/ofaa219
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32691007!7313774!32691007
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suck abstract from ncbi


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pmid32691007      Open+Forum+Infect+Dis 2020 ; 7 (7): ofaa219
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  • Countermeasures to Coronavirus Disease 2019: Are Immunomodulators Rational Treatment Options-A Critical Review of the Evidence #MMPMID32691007
  • Chastain DB; Stitt TM; Ly PT; Henao-Martinez AF; Franco-Paredes C; Osae SP
  • Open Forum Infect Dis 2020[Jul]; 7 (7): ofaa219 PMID32691007show ga
  • Severe acute respiratory syndrome coronavirus 2 is associated with higher concentrations of proinflammatory cytokines that lead to lung damage, respiratory failure, and resultant increased mortality. Immunomodulatory therapy has the potential to inhibit cytokines and quell the immune dysregulation. Controversial data found improved oxygenation after treatment with tocilizumab, an interleukin-6 inhibitor, sparking a wave of interest and resultant clinical trials evaluating immunomodulatory therapies. The purpose of this article is to assess potential proinflammatory targets and review the safety and efficacy of immunomodulatory therapies in managing patients with acute respiratory distress syndrome associated with coronavirus disease 2019.
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