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10.1016/j.jstrokecerebrovasdis.2020.104941 http://scihub22266oqcxt.onion/10.1016/j.jstrokecerebrovasdis.2020.104941 32689643!7214348!32689643     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Stroke+Cerebrovasc+Dis 2020 ; 29 (8): 104941 Nephropedia Template TP {{tp|p=32689643|t=2020. Coronavirus Disease 2019 and Stroke: Clinical Manifestations and Pathophysiological Insights |pdf=|usr=}}{{32689643}} gab.com Text Coronavirus Disease 2019 and Stroke: Clinical Manifestations and Pathophysiological Insights JO: J Stroke Cerebrovasc Dis http://www.kidney.de/pget.php?&tw=1&pmid=32689643 #FOAvip Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global health threat. Some COVID-19 patients have exhibited widespread neurological manifestations including stroke. Acute ischemic stroke, intracerebral hemorrhage, and cerebral venous sinus thrombosis have been reported in patients with COVID-19. COVID-19-associated coagulopathy is increasingly recognized as a result of acute infection and is likely caused by inflammation, including inflammatory cytokine storm. Recent studies suggest that axonal transport of SARS-CoV-2 to the brain can occur via the cribriform plate adjacent to the olfactory bulb that may lead to symptomatic anosmia. The internalization of SARS-CoV-2 is mediated by the binding of the spike glycoprotein of the virus to the angiotensin-converting enzyme 2 (ACE2) on cellular membranes. ACE2 is expressed in several tissues including lung alveolar cells, gastrointestinal tissue, and brain. The aim of this review is to provide insights into the clinical manifestations and pathophysiological mechanisms of stroke in COVID-19 patients. SARS-CoV-2 can down-regulate ACE2 and, in turn, overactivate the classical renin-angiotensin system (RAS) axis and decrease the activation of the alternative RAS pathway in the brain. The consequent imbalance in vasodilation, neuroinflammation, oxidative stress, and thrombotic response may contribute to the pathophysiology of stroke during SARS-CoV-2 infection. Twit Text FOAVip Coronavirus Disease 2019 and Stroke: Clinical Manifestations and Pathophysiological Insights ????J Stroke Cerebrovasc Dis http://www.kidney.de/pget.php?&tw=1&pmid=32689643 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32689643 #FOAvip English Wikipedia <ref>{{Cite pmid|32689643}}</ref> Coronavirus Disease 2019 and Stroke: Clinical Manifestations and Pathophysiological Insights #MMPMID32689643 Divani AA; Andalib S; Di Napoli M; Lattanzi S; Hussain MS; Biller J; McCullough LD; Azarpazhooh MR; Seletska A; Mayer SA; Torbey M J Stroke Cerebrovasc Dis 2020[Aug]; 29 (8): 104941 PMID32689643show ga Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global health threat. Some COVID-19 patients have exhibited widespread neurological manifestations including stroke. Acute ischemic stroke, intracerebral hemorrhage, and cerebral venous sinus thrombosis have been reported in patients with COVID-19. COVID-19-associated coagulopathy is increasingly recognized as a result of acute infection and is likely caused by inflammation, including inflammatory cytokine storm. Recent studies suggest that axonal transport of SARS-CoV-2 to the brain can occur via the cribriform plate adjacent to the olfactory bulb that may lead to symptomatic anosmia. The internalization of SARS-CoV-2 is mediated by the binding of the spike glycoprotein of the virus to the angiotensin-converting enzyme 2 (ACE2) on cellular membranes. ACE2 is expressed in several tissues including lung alveolar cells, gastrointestinal tissue, and brain. The aim of this review is to provide insights into the clinical manifestations and pathophysiological mechanisms of stroke in COVID-19 patients. SARS-CoV-2 can down-regulate ACE2 and, in turn, overactivate the classical renin-angiotensin system (RAS) axis and decrease the activation of the alternative RAS pathway in the brain. The consequent imbalance in vasodilation, neuroinflammation, oxidative stress, and thrombotic response may contribute to the pathophysiology of stroke during SARS-CoV-2 infection. |Angiotensin-Converting Enzyme 2[MESH] |Betacoronavirus/metabolism/*pathogenicity[MESH] |Blood Coagulation[MESH] |Brain/metabolism/*physiopathology/virology[MESH] |COVID-19[MESH] |Coronavirus Infections/epidemiology/metabolism/*physiopathology/virology[MESH] |Encephalitis, Viral/epidemiology/metabolism/*physiopathology/virology[MESH] |Host Microbial Interactions[MESH] |Humans[MESH] |Inflammation Mediators/metabolism[MESH] |Oxidative Stress[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/metabolism[MESH] |Pneumonia, Viral/epidemiology/metabolism/*physiopathology/virology[MESH] |Renin-Angiotensin System[MESH] |SARS-CoV-2[MESH] |Signal Transduction[MESH] |Spike Glycoprotein, Coronavirus/metabolism[MESH] |Stroke/epidemiology/metabolism/*physiopathology/virology[MESH] |Vasodilation[MESH]Coronavirus Disease 2019 and Stroke: Clinical Manifestations and Path(epmc).pdf DeepDyve Pubget Overpricing