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10.1016/j.lfs.2020.118113

http://scihub22266oqcxt.onion/10.1016/j.lfs.2020.118113
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32687919!7366115!32687919
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suck abstract from ncbi


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pmid32687919      Life+Sci 2020 ; 257 (ä): 118113
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  • A lung for all: Novel mechanical ventilator for emergency and low-resource settings #MMPMID32687919
  • Zuckerberg J; Shaik M; Widmeier K; Kilbaugh T; Nelin TD
  • Life Sci 2020[Sep]; 257 (ä): 118113 PMID32687919show ga
  • AIMS: To create a low-cost ventilator that could be constructed with readily-available hospital equipment for use in emergency or low-resource settings. MAIN METHODS: The novel ventilator consists of an inspiratory limb composed of an elastic flow-inflating bag encased within a non-compliant outer sheath and an expiratory limb composed of a series of two, one-way bidirectional splitter valves derived from a self-inflating bag system. An Arduino Uno microcontroller controls a solenoid valve that can be programmed to open and close to produce a set respiratory rate and inspiratory time. Using an ASL 5000 Lung Simulator, we obtained flow, pressure, and volume waveforms at different lung compliances. KEY FINDINGS: At a static lung compliance of 50 mL/cm H(2)O and an airway resistance of 6 cm H(2)O/L/s, ventilated at a PIP and PEEP of 16 and 5 cm H(2)O, respectively, tidal volumes of approximately 540 mL were achieved. At a static lung compliance of 20 mL/cm H(2)O and an airway resistance of 6 cm H(2)O/L/s, ventilated at a PIP and PEEP of 38 and 15 cm H(2)O, respectively, tidal volumes of approximately 495 mL were achieved. SIGNIFICANCE: This novel ventilator is able to safely and reliably ventilate patients with a range of pulmonary disease in a simulated setting. Opportunities exist to utilize our ventilator in emergency situations and low-resource settings.
  • |Airway Resistance/physiology[MESH]
  • |Betacoronavirus/pathogenicity[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*physiopathology[MESH]
  • |Humans[MESH]
  • |Lung/physiology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*physiopathology[MESH]
  • |Respiration, Artificial/*instrumentation/*methods[MESH]
  • |Respiratory Rate/physiology[MESH]
  • |SARS-CoV-2[MESH]
  • |Tidal Volume/physiology[MESH]


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