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10.1021/acsinfecdis.0c00343 http://scihub22266oqcxt.onion/10.1021/acsinfecdis.0c00343 32687696!ä!32687696 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Infect+Dis 2020 ; 6 (9): 2304-2318 Nephropedia Template TP {{tp|p=32687696|t=2020. Old Drugs for a New Virus: Repurposed Approaches for Combating COVID-19 |pdf=|usr=}}{{32687696}} gab.com Text Old Drugs for a New Virus: Repurposed Approaches for Combating COVID-19 JO: ACS Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=32687696 #FOAvip There is a large global unmet need for effective countermeasures to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19). The development of novel antiviral drugs is expensive and too slow to meet the immediate need. The repurposing of drugs that are approved or are under advanced clinical investigation provides a cost- and time-effective therapeutic solution. This review summarizes the major repurposed approaches that have been proposed or are already being studied in clinical trials for COVID-19. Among these approaches are drugs that aim to reduce SARS-CoV-2 replication by targeting either viral enzymatic functions or cellular factors required for the viral life cycle. Drugs that modulate the host immune response to SARS-CoV-2 infection by boosting it to enhance viral clearance or by suppressing it to prevent excessive inflammation and tissue injury represent another category. Lastly, we discuss means to discover repurposed drugs and the ongoing challenges associated with the off-label use of existing drugs in the context of the COVID-19 outbreak. Twit Text FOAVip Old Drugs for a New Virus: Repurposed Approaches for Combating COVID-19 ????ACS Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=32687696 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32687696 #FOAvip English Wikipedia <ref>{{Cite pmid|32687696}}</ref> Old Drugs for a New Virus: Repurposed Approaches for Combating COVID-19 #MMPMID32687696 Saul S; Einav S ACS Infect Dis 2020[Sep]; 6 (9): 2304-2318 PMID32687696show ga There is a large global unmet need for effective countermeasures to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19). The development of novel antiviral drugs is expensive and too slow to meet the immediate need. The repurposing of drugs that are approved or are under advanced clinical investigation provides a cost- and time-effective therapeutic solution. This review summarizes the major repurposed approaches that have been proposed or are already being studied in clinical trials for COVID-19. Among these approaches are drugs that aim to reduce SARS-CoV-2 replication by targeting either viral enzymatic functions or cellular factors required for the viral life cycle. Drugs that modulate the host immune response to SARS-CoV-2 infection by boosting it to enhance viral clearance or by suppressing it to prevent excessive inflammation and tissue injury represent another category. Lastly, we discuss means to discover repurposed drugs and the ongoing challenges associated with the off-label use of existing drugs in the context of the COVID-19 outbreak. |*Drug Repositioning[MESH] |Animals[MESH] |Anti-Inflammatory Agents/therapeutic use[MESH] |Antiviral Agents/*therapeutic use[MESH] |Betacoronavirus/*drug effects/isolation & purification[MESH] |COVID-19[MESH] |Coronavirus Infections/*drug therapy/immunology/virology[MESH] |Humans[MESH] |Inflammation/immunology/prevention & control/virology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy/immunology/virology[MESH] |SARS-CoV-2[MESH]Old Drugs for a New Virus: Repurposed Approaches for Combating COVID-1(epmc).pdf DeepDyve Pubget Overpricing