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10.1152/ajpcell.00260.2020 http://scihub22266oqcxt.onion/10.1152/ajpcell.00260.2020 32687406!7839238!32687406     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol+Cell+Physiol 2020 ; 319 (3): C500-C509 Nephropedia Template TP {{tp|p=32687406|t=2020. Inhibiting fusion with cellular membrane system: therapeutic options to prevent severe acute respiratory syndrome coronavirus-2 infection |pdf=|usr=}}{{32687406}} gab.com Text Inhibiting fusion with cellular membrane system: therapeutic options to prevent severe acute respiratory syndrome coronavirus-2 infection JO: Am J Physiol Cell Physiol http://www.kidney.de/pget.php?&tw=1&pmid=32687406 #FOAvip Severe acute respiratory syndrome coronavirus (SARS-CoV), an enveloped virus with a positive-sense single-stranded RNA genome, facilitates the host cell entry through intricate interactions with proteins and lipids of the cell membrane. The detailed molecular mechanism involves binding to the host cell receptor and fusion at the plasma membrane or after being trafficked to late endosomes under favorable environmental conditions. A crucial event in the process is the proteolytic cleavage of the viral spike protein by the host's endogenous proteases that releases the fusion peptide enabling fusion with the host cellular membrane system. The present review details the mechanism of viral fusion with the host and highlights the therapeutic options that prevent SARS-CoV-2 entry in humans. Twit Text FOAVip Inhibiting fusion with cellular membrane system: therapeutic options to prevent severe acute respiratory syndrome coronavirus-2 infection ????Am J Physiol Cell Physiol http://www.kidney.de/pget.php?&tw=1&pmid=32687406 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32687406 #FOAvip English Wikipedia <ref>{{Cite pmid|32687406}}</ref> Inhibiting fusion with cellular membrane system: therapeutic options to prevent severe acute respiratory syndrome coronavirus-2 infection #MMPMID32687406 Mitra P Am J Physiol Cell Physiol 2020[Sep]; 319 (3): C500-C509 PMID32687406show ga Severe acute respiratory syndrome coronavirus (SARS-CoV), an enveloped virus with a positive-sense single-stranded RNA genome, facilitates the host cell entry through intricate interactions with proteins and lipids of the cell membrane. The detailed molecular mechanism involves binding to the host cell receptor and fusion at the plasma membrane or after being trafficked to late endosomes under favorable environmental conditions. A crucial event in the process is the proteolytic cleavage of the viral spike protein by the host's endogenous proteases that releases the fusion peptide enabling fusion with the host cellular membrane system. The present review details the mechanism of viral fusion with the host and highlights the therapeutic options that prevent SARS-CoV-2 entry in humans. |Amino Acid Sequence[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Animals[MESH] |Betacoronavirus/drug effects/*metabolism[MESH] |COVID-19[MESH] |Cell Membrane/drug effects/*metabolism/virology[MESH] |Coronavirus Infections/*metabolism/*prevention & control[MESH] |Humans[MESH] |Pandemics/*prevention & control[MESH] |Peptidyl-Dipeptidase A/metabolism[MESH] |Pneumonia, Viral/*metabolism/*prevention & control[MESH] |Protease Inhibitors/pharmacology/therapeutic use[MESH] |Protein Binding/drug effects/physiology[MESH] |SARS-CoV-2[MESH] |Spike Glycoprotein, Coronavirus/antagonists & inhibitors/metabolism[MESH]Inhibiting fusion with cellular membrane system: therapeutic options t(epmc).pdf DeepDyve Pubget Overpricing