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10.4155/bio-2020-0063

http://scihub22266oqcxt.onion/10.4155/bio-2020-0063
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32686955!ä!32686955

suck abstract from ncbi


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pmid32686955      Bioanalysis 2020 ; 12 (13): 919-935
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  • Evaluation of a novel blood microsampling device for clinical trial sample collection and protein biomarker analysis #MMPMID32686955
  • Xing J; Loureiro J; Patel MT; Mikhailov D; Gusev AI
  • Bioanalysis 2020[Jul]; 12 (13): 919-935 PMID32686955show ga
  • Aim: Evaluation of a novel microsampling device for its use in clinical sample collection and biomarker analysis. Methodology: Matching samples were collected from 16 healthy donors (ten females, six males; age 42 +/- 20) via K2EDTA touch activated phlebotomy (TAP) device and phlebotomy. The protein profile differences between sampling groups was evaluated using aptamer-based proteomic assay SomaScan and selected ELISA. Conclusion: Somascan signal concordance between phlebotomy- and TAP-generated samples was studied and comparability of protein abundances between these blood sample collection methods was demonstrated. Statistically significant correlation in selected ELISA assays also confirmed the TAP device applicability to the quantitative analysis of protein biomarkers in clinical trials.
  • |Adult[MESH]
  • |Biomarkers/blood[MESH]
  • |Blood Proteins/*analysis[MESH]
  • |COVID-19[MESH]
  • |Clinical Trials as Topic[MESH]
  • |Coronavirus Infections/blood[MESH]
  • |Enzyme-Linked Immunosorbent Assay[MESH]
  • |Female[MESH]
  • |Hemolysis[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Phlebotomy/*instrumentation[MESH]
  • |Pneumonia, Viral/blood[MESH]
  • |Proteomics/instrumentation[MESH]


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